Abstract
Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 731-733 |
| Number of pages | 3 |
| Journal | Cancer treatment reports |
| Volume | 67 |
| Issue number | 7-8 |
| State | Published - 1983 |
| Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research