Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.
|Original language||English (US)|
|Number of pages||3|
|Journal||Cancer Treatment Reports|
|State||Published - Jan 1 1983|
ASJC Scopus subject areas
- Cancer Research