Enhancement of rat heart microsomal lipid peroxidation following doxorubicin treatment in vivo

E. G. Mimnaugh, M. A. Trush, T. E. Gram

Research output: Contribution to journalArticlepeer-review

Abstract

Cardiac microsomes from rats injected with doxorubicin (5 mg/kg ip x 3) were susceptible to dramatically enhanced NADPH-dependent lipid peroxidation in the presence of doxorubicin in vitro (18-fold increases over control peroxidation). These results suggest that doxorubicin treatment in vivo caused biochemical alterations which predisposed cardiac microsomal membranes to attack by anthracycline free radical-generated oxyradicals.

Original languageEnglish (US)
Pages (from-to)731-733
Number of pages3
JournalCancer Treatment Reports
Volume67
Issue number7-8
StatePublished - Jan 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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