Enhancement of radiotherapy with human mesenchymal stem cells containing gold nanoparticles

Mrudula Pullambhatla, Steven P. Rowe, Ala Lisok, Yuchuan Wang, Gabriele Putz Todd, Alla Danilkovitch, Martin G. Pomper

Research output: Contribution to journalArticlepeer-review

Abstract

Radiotherapy is a common approach for the treatment of a wide variety of cancer types. Available data indicate that nanoparticles can enhance the effect of radiotherapy. We report the use of human mesenchymal stem cells to selectively deliver gold nanoparticles (GNPs) to MDA-MB-231 breast tumor xenografts in mice for the purpose of enhancing the effect of radiation therapy. Targeted delivery of GNPs to the tumor site, followed by irradiation of the tumor, enabled control of tumor growth. The results indicate that tumor-selective GNP delivery by human mesenchymal stem cells may represent a viable way to enhance the effectiveness of radiotherapy.

Original languageEnglish (US)
Pages (from-to)373-378
Number of pages6
JournalTomography (Ann Arbor, Mich.)
Volume6
Issue number4
DOIs
StatePublished - 2020

Keywords

  • Breast cancer
  • MSCs
  • Molecular imaging
  • Nanomedicine
  • Targeted delivery
  • Tumor microenvironment

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

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