Enhancement in 'apparent' membrane microviscosity during differentiation of embryonal carcinoma cells induced by retinoids

Anton M. Jetten, Luigi M. De Luca, Robert G. Meeks

Research output: Contribution to journalArticlepeer-review

Abstract

Upon differentiation of embryonal carcinoma cells induced by retinoids (10-7 M) the 'apparent' membrane microviscosity increases dramatically. Only biologically active retinoids induce differentiation and cause an enhancement in microviscosity. Several embryonal carcinoma cell lines have a relatively lower 'apparent' microviscosity than their differentiated derivatives, suggesting that this may be a general property of these cells. At higher concentrations retinoids cause a reduction in 'apparent' membrane microviscosity of various cells. This change occurs whether the analogue is biologically active or not, indicating the non-specific nature of this action.

Original languageEnglish (US)
Pages (from-to)494-498
Number of pages5
JournalExperimental cell research
Volume138
Issue number2
DOIs
StatePublished - Apr 1982
Externally publishedYes

ASJC Scopus subject areas

  • Cell Biology

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