Enhanced scratching elicited by a pruritogen and an algogen in a mouse model of contact hypersensitivity

Kai Fu, Lintao Qu, Steven G. Shimada, Hong Nie, Robert H. LaMotte

Research output: Contribution to journalComment/debatepeer-review

18 Scopus citations


Chemical pruritogens and algogens evoke primarily itch and pain, respectively, when administered to the skin of healthy human subjects. However, the dominant sensory quality elicited by an algesic chemical stimulus may change in patients with chronic itch where bradykinin, elicits itch in addition to pain. Here we tested whether normally pruritic and algesic chemicals evoked abnormal itch- or pain-like behaviors in the mouse after the development of contact hypersensitivity (CHS), an animal model of allergic contact dermatitis. Mice previously sensitized to a hapten (squaric acid dibutylester) applied to the abdomen, exhibited spontaneous itch-like scratching and pain-like wiping directed to the site on the cheek of the CHS elicited by a subsequent challenge with the same hapten. In comparison with responses of control mice, CHS mice exhibited a significant increase in the scratching evoked by bovine adrenal medulla 8-22, a peptide that elicits a histamine-independent itch, but did not alter the scratching to histamine. Bradykinin, an algogen that elicited only wiping in control mice, additionally evoked significant scratching in CHS mice. Thus, within an area of CHS, histamine-independent itch is enhanced and chemically evoked pain is accompanied by itch.

Original languageEnglish (US)
Pages (from-to)190-194
Number of pages5
JournalNeuroscience Letters
StatePublished - Sep 5 2014
Externally publishedYes


  • Algogen
  • Contact hypersensitivity
  • Itch
  • Pain
  • Pruritogen

ASJC Scopus subject areas

  • Neuroscience(all)


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