Enhanced production of human immunodeficiency virus type 1 by in vitro-infected alveolar macrophages from otherwise healthy cigarette smokers

Rita A. Abbud, Candace K. Finegan, Laura A. Guay, Elizabeth A. Rich

Research output: Contribution to journalArticlepeer-review

Abstract

Since cellular activation is required for replication of human immunodeficiency virus type 1 (HIV-1), the capacity of alveolar macrophages (AM) from smokers, which are relatively activated, and nonsmokers to support the production of HIV-1JR-FLwas examined. Peak HIV-1 p24 antigen level in culture supernatants of infected AM from 13 smokers was significantly higher than that of 13 nonsmokers: 31, 394 ± 8295 versus 7037 ± 2550 pg/mL (mean ± SE; p

Original languageEnglish (US)
Pages (from-to)859-863
Number of pages5
JournalJournal of Infectious Diseases
Volume172
Issue number3
DOIs
StatePublished - 1995
Externally publishedYes

ASJC Scopus subject areas

  • Infectious Diseases
  • Immunology and Allergy
  • Immunology
  • Public Health, Environmental and Occupational Health

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