Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Virginia L. Kan, Antonia Geber, John E. Bennett

Research output: Contribution to journalArticlepeer-review

Abstract

The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

Original languageEnglish (US)
Pages (from-to)1717-1719
Number of pages3
JournalAntimicrobial agents and chemotherapy
Volume40
Issue number7
DOIs
StatePublished - Jul 1996

ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

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