Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Virginia L. Kan; Antonia Geber; John E. Bennett

doi:10.1128/aac.40.7.1717

Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Virginia L. Kan, Antonia Geber, John E. Bennett

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The susceptibility of genetically defined Candida glabrata strains to killing by H₂O₂ and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H₂O₂ and neutrophils.

Original language	English (US)
Pages (from-to)	1717-1719
Number of pages	3
Journal	Antimicrobial agents and chemotherapy
Volume	40
Issue number	7
DOIs	https://doi.org/10.1128/aac.40.7.1717
State	Published - Jul 1996
Externally published	Yes

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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title = "Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion",

abstract = "The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.",

author = "Kan, {Virginia L.} and Antonia Geber and Bennett, {John E.}",

year = "1996",

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AU - Geber, Antonia

AU - Bennett, John E.

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N2 - The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

AB - The susceptibility of genetically defined Candida glabrata strains to killing by H2O2 and neutrophils was assessed. Fluconazole-susceptible L5L and L5D strains demonstrated survival rates higher than those of two fluconazole-resistant strains lacking the ERG11 gene coding for 14α- demethylase. Fluconazole resistance can occur by mechanisms which increase fungal susceptibility to oxidative killing by H2O2 and neutrophils.

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Enhanced oxidative killing of azole-resistant Candida glabrata strains with ERG11 deletion

Abstract

ASJC Scopus subject areas

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