TY - JOUR
T1 - Enhanced malaria parasite transmission from helminth co-infected mice
AU - Noland, Gregory S.
AU - Graczyk, Thaddeus K.
AU - Fried, Bernard
AU - Kumar, Nirbhay
PY - 2007/6
Y1 - 2007/6
N2 - Helminth infections are prevalent in malaria-endemic areas, yet the potential for helminths to alter malaria transmission has not been closely examined. We used the Echinostoma caproni-Plasmodium yoelii murine model of co-infection to assess the impact of helminth co-infection on malaria transmission. In four replicate experiments, Anopheles stephensi mosquitoes exposed to co-infected mice five days post-malaria infection had a higher rate of infectivity (80.1%, n = 241) than those exposed to malaria only-infected mice (72.0%, n = 232, P = 0.039). Intensity of malaria parasite transmission was also greater, with approximately two-fold more oocysts (geometric mean = 19.2 versus 10.5, P = 0.004) and an increase in sporozoite burden observed in mosquitoes exposed to co-infected mice. Malaria parasite prevalence and anemia were similar between co-infected and malaria only-infected mice, which suggested that enhanced malaria parasite transmission was due to helminth-induced modulation of host responses.
AB - Helminth infections are prevalent in malaria-endemic areas, yet the potential for helminths to alter malaria transmission has not been closely examined. We used the Echinostoma caproni-Plasmodium yoelii murine model of co-infection to assess the impact of helminth co-infection on malaria transmission. In four replicate experiments, Anopheles stephensi mosquitoes exposed to co-infected mice five days post-malaria infection had a higher rate of infectivity (80.1%, n = 241) than those exposed to malaria only-infected mice (72.0%, n = 232, P = 0.039). Intensity of malaria parasite transmission was also greater, with approximately two-fold more oocysts (geometric mean = 19.2 versus 10.5, P = 0.004) and an increase in sporozoite burden observed in mosquitoes exposed to co-infected mice. Malaria parasite prevalence and anemia were similar between co-infected and malaria only-infected mice, which suggested that enhanced malaria parasite transmission was due to helminth-induced modulation of host responses.
UR - http://www.scopus.com/inward/record.url?scp=34548040749&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=34548040749&partnerID=8YFLogxK
U2 - 10.4269/ajtmh.2007.76.1052
DO - 10.4269/ajtmh.2007.76.1052
M3 - Article
C2 - 17556610
AN - SCOPUS:34548040749
VL - 76
SP - 1052
EP - 1056
JO - American Journal of Tropical Medicine and Hygiene
JF - American Journal of Tropical Medicine and Hygiene
SN - 0002-9637
IS - 6
ER -