Enhanced malaria parasite transmission from helminth co-infected mice

Gregory S. Noland, Thaddeus K. Graczyk, Bernard Fried, Nirbhay Kumar

Research output: Contribution to journalArticle

Abstract

Helminth infections are prevalent in malaria-endemic areas, yet the potential for helminths to alter malaria transmission has not been closely examined. We used the Echinostoma caproni-Plasmodium yoelii murine model of co-infection to assess the impact of helminth co-infection on malaria transmission. In four replicate experiments, Anopheles stephensi mosquitoes exposed to co-infected mice five days post-malaria infection had a higher rate of infectivity (80.1%, n = 241) than those exposed to malaria only-infected mice (72.0%, n = 232, P = 0.039). Intensity of malaria parasite transmission was also greater, with approximately two-fold more oocysts (geometric mean = 19.2 versus 10.5, P = 0.004) and an increase in sporozoite burden observed in mosquitoes exposed to co-infected mice. Malaria parasite prevalence and anemia were similar between co-infected and malaria only-infected mice, which suggested that enhanced malaria parasite transmission was due to helminth-induced modulation of host responses.

Original languageEnglish (US)
Pages (from-to)1052-1056
Number of pages5
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume76
Issue number6
StatePublished - Jun 1 2007

ASJC Scopus subject areas

  • Parasitology
  • Virology
  • Infectious Diseases

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  • Cite this

    Noland, G. S., Graczyk, T. K., Fried, B., & Kumar, N. (2007). Enhanced malaria parasite transmission from helminth co-infected mice. American Journal of Tropical Medicine and Hygiene, 76(6), 1052-1056.