TY - JOUR
T1 - Enhanced interrogation
T2 - Emerging strategies for cell signaling inhibition
AU - Huang, Rong
AU - Martinez-Ferrando, Isabel
AU - Cole, Philip A.
N1 - Funding Information:
We are grateful for helpful suggestions from members of our laboratory and other collaborators and thank the US National Institutes of Health for financial support.
PY - 2010/6
Y1 - 2010/6
N2 - Here we summarize recent and developing chemical approaches for modulating signaling pathways. In particular, we discuss targeting mutant signaling proteins, disrupting protein-protein interactions in cellular signaling networks, designing bivalent inhibitors of signaling proteins and identifying allosteric regulators of signaling enzymes. Over the past decade, great progress in the harvesting of chemical tools for basic research and clinical medicine has been made, but many challenges remain, and examples of exciting future targets are highlighted.
AB - Here we summarize recent and developing chemical approaches for modulating signaling pathways. In particular, we discuss targeting mutant signaling proteins, disrupting protein-protein interactions in cellular signaling networks, designing bivalent inhibitors of signaling proteins and identifying allosteric regulators of signaling enzymes. Over the past decade, great progress in the harvesting of chemical tools for basic research and clinical medicine has been made, but many challenges remain, and examples of exciting future targets are highlighted.
UR - http://www.scopus.com/inward/record.url?scp=77953266002&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=77953266002&partnerID=8YFLogxK
U2 - 10.1038/nsmb0610-646
DO - 10.1038/nsmb0610-646
M3 - Comment/debate
C2 - 20520657
AN - SCOPUS:77953266002
SN - 1545-9993
VL - 17
SP - 646
EP - 649
JO - Nature Structural and Molecular Biology
JF - Nature Structural and Molecular Biology
IS - 6
ER -