Enhanced interrogation: Emerging strategies for cell signaling inhibition

Rong Huang, Isabel Martinez-Ferrando, Philip A. Cole

Research output: Contribution to journalComment/debate

Abstract

Here we summarize recent and developing chemical approaches for modulating signaling pathways. In particular, we discuss targeting mutant signaling proteins, disrupting protein-protein interactions in cellular signaling networks, designing bivalent inhibitors of signaling proteins and identifying allosteric regulators of signaling enzymes. Over the past decade, great progress in the harvesting of chemical tools for basic research and clinical medicine has been made, but many challenges remain, and examples of exciting future targets are highlighted.

Original languageEnglish (US)
Pages (from-to)646-649
Number of pages4
JournalNature Structural and Molecular Biology
Volume17
Issue number6
DOIs
StatePublished - Jun 1 2010

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ASJC Scopus subject areas

  • Structural Biology
  • Molecular Biology

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