Enhanced hemostatic indices in patients with pulmonary arterial hypertension: An observational study

Mehmet Mustafa Can, Ibrahim Halil Tanboǧa, Hacer Ceren Demircan, Alper Özkan, Fatih Koca, Nurşen Keleş, Kenan Sönmez, Cihangir Kaymaz, Victor Serebruany

Research output: Contribution to journalArticlepeer-review

32 Scopus citations


Background: Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Regardless of the initial trigger, the elevated pulmonary arterial pressure and vascular resistance in patients with PAH are primarily caused by remodeling and thrombosis of small- and medium-sized pulmonary arteries and arterioles, as well as sustained vasoconstriction. Recent studies have emphasized the relevance of several biomarkers of hemostasis in the PAH progression. However, there is no agreement whether hemostatic indices are indeed distinguishing PAH patients from controls. Methods: Plasma fibrinogen, D-dimer, platelet count, and mean platelet volume, and platelet aggregation induced by ADP and collagen were serially measured in 34 patients with PAH, and 34 matched by age and sex normal volunteers. Results: Hemostatic indices were significantly higher for fibrinogen (p = 0.0001), D-dimer (p = 0.001), mean platelet volume (p = 0.001), and platelet aggregation induced by ADP-, and collagen (p = 0.0001 for both) in PAH pstients when compared to healthy controls. In contrast, platelet counts were almost identical between both groups. Conclusions: Patients with PAH exhibit activation of hemostatic indices compared to healthy controls. These data support previous observations that hemostatic abnormalities including platelet activation may directly impact pathogenesis of PAH, and need to be confirmed in larger randomized studies with more comprehensive assessment of hemostatic indices for justification of antithrombotic strategies.

Original languageEnglish (US)
Pages (from-to)280-282
Number of pages3
JournalThrombosis Research
Issue number4
StatePublished - Oct 2010


  • Hemostasis
  • Platelets
  • Pulmonary Arterial Hypertension

ASJC Scopus subject areas

  • Hematology


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