Enhanced hemostatic indices in patients with pulmonary arterial hypertension

An observational study

Mehmet Mustafa Can, Ibrahim Halil Tanboǧa, Hacer Ceren Demircan, Alper Özkan, Fatih Koca, Nurşen Keleş, Kenan Sönmez, Cihangir Kaymaz, Victor Serebruany

Research output: Contribution to journalArticle

Abstract

Background: Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Regardless of the initial trigger, the elevated pulmonary arterial pressure and vascular resistance in patients with PAH are primarily caused by remodeling and thrombosis of small- and medium-sized pulmonary arteries and arterioles, as well as sustained vasoconstriction. Recent studies have emphasized the relevance of several biomarkers of hemostasis in the PAH progression. However, there is no agreement whether hemostatic indices are indeed distinguishing PAH patients from controls. Methods: Plasma fibrinogen, D-dimer, platelet count, and mean platelet volume, and platelet aggregation induced by ADP and collagen were serially measured in 34 patients with PAH, and 34 matched by age and sex normal volunteers. Results: Hemostatic indices were significantly higher for fibrinogen (p = 0.0001), D-dimer (p = 0.001), mean platelet volume (p = 0.001), and platelet aggregation induced by ADP-, and collagen (p = 0.0001 for both) in PAH pstients when compared to healthy controls. In contrast, platelet counts were almost identical between both groups. Conclusions: Patients with PAH exhibit activation of hemostatic indices compared to healthy controls. These data support previous observations that hemostatic abnormalities including platelet activation may directly impact pathogenesis of PAH, and need to be confirmed in larger randomized studies with more comprehensive assessment of hemostatic indices for justification of antithrombotic strategies.

Original languageEnglish (US)
Pages (from-to)280-282
Number of pages3
JournalThrombosis Research
Volume126
Issue number4
DOIs
StatePublished - Oct 2010

Fingerprint

Hemostatics
Pulmonary Hypertension
Observational Studies
Mean Platelet Volume
Platelet Count
Platelet Aggregation
Adenosine Diphosphate
Fibrinogen
Pulmonary Artery
Collagen
Platelet Activation
Arterioles
Vasoconstriction
Hemostasis
Vascular Resistance
Healthy Volunteers
Arterial Pressure
Thrombosis
Chronic Disease
Biomarkers

Keywords

  • Hemostasis
  • Platelets
  • Pulmonary Arterial Hypertension

ASJC Scopus subject areas

  • Hematology

Cite this

Can, M. M., Tanboǧa, I. H., Demircan, H. C., Özkan, A., Koca, F., Keleş, N., ... Serebruany, V. (2010). Enhanced hemostatic indices in patients with pulmonary arterial hypertension: An observational study. Thrombosis Research, 126(4), 280-282. https://doi.org/10.1016/j.thromres.2010.06.020

Enhanced hemostatic indices in patients with pulmonary arterial hypertension : An observational study. / Can, Mehmet Mustafa; Tanboǧa, Ibrahim Halil; Demircan, Hacer Ceren; Özkan, Alper; Koca, Fatih; Keleş, Nurşen; Sönmez, Kenan; Kaymaz, Cihangir; Serebruany, Victor.

In: Thrombosis Research, Vol. 126, No. 4, 10.2010, p. 280-282.

Research output: Contribution to journalArticle

Can, MM, Tanboǧa, IH, Demircan, HC, Özkan, A, Koca, F, Keleş, N, Sönmez, K, Kaymaz, C & Serebruany, V 2010, 'Enhanced hemostatic indices in patients with pulmonary arterial hypertension: An observational study', Thrombosis Research, vol. 126, no. 4, pp. 280-282. https://doi.org/10.1016/j.thromres.2010.06.020
Can, Mehmet Mustafa ; Tanboǧa, Ibrahim Halil ; Demircan, Hacer Ceren ; Özkan, Alper ; Koca, Fatih ; Keleş, Nurşen ; Sönmez, Kenan ; Kaymaz, Cihangir ; Serebruany, Victor. / Enhanced hemostatic indices in patients with pulmonary arterial hypertension : An observational study. In: Thrombosis Research. 2010 ; Vol. 126, No. 4. pp. 280-282.
@article{c8a8525b601c45dfa99cdd9fd20c5374,
title = "Enhanced hemostatic indices in patients with pulmonary arterial hypertension: An observational study",
abstract = "Background: Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Regardless of the initial trigger, the elevated pulmonary arterial pressure and vascular resistance in patients with PAH are primarily caused by remodeling and thrombosis of small- and medium-sized pulmonary arteries and arterioles, as well as sustained vasoconstriction. Recent studies have emphasized the relevance of several biomarkers of hemostasis in the PAH progression. However, there is no agreement whether hemostatic indices are indeed distinguishing PAH patients from controls. Methods: Plasma fibrinogen, D-dimer, platelet count, and mean platelet volume, and platelet aggregation induced by ADP and collagen were serially measured in 34 patients with PAH, and 34 matched by age and sex normal volunteers. Results: Hemostatic indices were significantly higher for fibrinogen (p = 0.0001), D-dimer (p = 0.001), mean platelet volume (p = 0.001), and platelet aggregation induced by ADP-, and collagen (p = 0.0001 for both) in PAH pstients when compared to healthy controls. In contrast, platelet counts were almost identical between both groups. Conclusions: Patients with PAH exhibit activation of hemostatic indices compared to healthy controls. These data support previous observations that hemostatic abnormalities including platelet activation may directly impact pathogenesis of PAH, and need to be confirmed in larger randomized studies with more comprehensive assessment of hemostatic indices for justification of antithrombotic strategies.",
keywords = "Hemostasis, Platelets, Pulmonary Arterial Hypertension",
author = "Can, {Mehmet Mustafa} and Tanboǧa, {Ibrahim Halil} and Demircan, {Hacer Ceren} and Alper {\"O}zkan and Fatih Koca and Nurşen Keleş and Kenan S{\"o}nmez and Cihangir Kaymaz and Victor Serebruany",
year = "2010",
month = "10",
doi = "10.1016/j.thromres.2010.06.020",
language = "English (US)",
volume = "126",
pages = "280--282",
journal = "Thrombosis Research",
issn = "0049-3848",
publisher = "Elsevier Limited",
number = "4",

}

TY - JOUR

T1 - Enhanced hemostatic indices in patients with pulmonary arterial hypertension

T2 - An observational study

AU - Can, Mehmet Mustafa

AU - Tanboǧa, Ibrahim Halil

AU - Demircan, Hacer Ceren

AU - Özkan, Alper

AU - Koca, Fatih

AU - Keleş, Nurşen

AU - Sönmez, Kenan

AU - Kaymaz, Cihangir

AU - Serebruany, Victor

PY - 2010/10

Y1 - 2010/10

N2 - Background: Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Regardless of the initial trigger, the elevated pulmonary arterial pressure and vascular resistance in patients with PAH are primarily caused by remodeling and thrombosis of small- and medium-sized pulmonary arteries and arterioles, as well as sustained vasoconstriction. Recent studies have emphasized the relevance of several biomarkers of hemostasis in the PAH progression. However, there is no agreement whether hemostatic indices are indeed distinguishing PAH patients from controls. Methods: Plasma fibrinogen, D-dimer, platelet count, and mean platelet volume, and platelet aggregation induced by ADP and collagen were serially measured in 34 patients with PAH, and 34 matched by age and sex normal volunteers. Results: Hemostatic indices were significantly higher for fibrinogen (p = 0.0001), D-dimer (p = 0.001), mean platelet volume (p = 0.001), and platelet aggregation induced by ADP-, and collagen (p = 0.0001 for both) in PAH pstients when compared to healthy controls. In contrast, platelet counts were almost identical between both groups. Conclusions: Patients with PAH exhibit activation of hemostatic indices compared to healthy controls. These data support previous observations that hemostatic abnormalities including platelet activation may directly impact pathogenesis of PAH, and need to be confirmed in larger randomized studies with more comprehensive assessment of hemostatic indices for justification of antithrombotic strategies.

AB - Background: Pulmonary arterial hypertension (PAH) is a chronic progressive disease characterized by persistent elevation of pulmonary artery pressure. Regardless of the initial trigger, the elevated pulmonary arterial pressure and vascular resistance in patients with PAH are primarily caused by remodeling and thrombosis of small- and medium-sized pulmonary arteries and arterioles, as well as sustained vasoconstriction. Recent studies have emphasized the relevance of several biomarkers of hemostasis in the PAH progression. However, there is no agreement whether hemostatic indices are indeed distinguishing PAH patients from controls. Methods: Plasma fibrinogen, D-dimer, platelet count, and mean platelet volume, and platelet aggregation induced by ADP and collagen were serially measured in 34 patients with PAH, and 34 matched by age and sex normal volunteers. Results: Hemostatic indices were significantly higher for fibrinogen (p = 0.0001), D-dimer (p = 0.001), mean platelet volume (p = 0.001), and platelet aggregation induced by ADP-, and collagen (p = 0.0001 for both) in PAH pstients when compared to healthy controls. In contrast, platelet counts were almost identical between both groups. Conclusions: Patients with PAH exhibit activation of hemostatic indices compared to healthy controls. These data support previous observations that hemostatic abnormalities including platelet activation may directly impact pathogenesis of PAH, and need to be confirmed in larger randomized studies with more comprehensive assessment of hemostatic indices for justification of antithrombotic strategies.

KW - Hemostasis

KW - Platelets

KW - Pulmonary Arterial Hypertension

UR - http://www.scopus.com/inward/record.url?scp=77957139130&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77957139130&partnerID=8YFLogxK

U2 - 10.1016/j.thromres.2010.06.020

DO - 10.1016/j.thromres.2010.06.020

M3 - Article

VL - 126

SP - 280

EP - 282

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 4

ER -