TY - JOUR
T1 - Enhanced gallbladder absorption during gallstone formation
T2 - The roles of cholesterol saturated bile and gallbladder stasis
AU - Roslyn, J. J.
AU - Doty, J.
AU - Pitt, H. A.
AU - Conter, R. L.
AU - Den Besten, L.
N1 - Funding Information:
From the Surgical Service, Sepulveda Veterans Administration Medical Center, Sepulveda, and Department of Surgery, U.C.LA. School of Medicine, Los Angeles, California. Supported by a Veterans Administration research grant. Presented in part at Eastern Region, American Federation for Clinical Research, Philadelphia, October 18, 1984 and appeared in abstract form in 1984 (Clin Res 32:745A, 1984). Reprint requests: Joel J. Roslyn, MD, Division of General Surgery, UCLA School of Medicine, Los Angeles, CA 90024.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 1986
Y1 - 1986
N2 - Cholesterol saturated bile and gallbladder stasis are important factors in the pathogenesis of cholesterol gallstones. The degree to which either or both of these factors affect gallbladder transport of fluid remains obscure. The authors tested the hypothesis that both cholesterol saturated bile and gallbladder stasis, and not stasis alone, promoters gallbladder fluid absorption. Prairie dogs were maintained for 2 weeks on either a control chow, total parenteral nutrition (TPN), or a 1.2% cholesterol enriched chow. The bile acid pool was labeled with 14C-cholic acid and indexes for cholesterol saturation (CSI) and gallbladder stasis (Rsa) were determined. Fluid transport was indirectly measured by calculating the ratio of gallbladder to hepatic bile concentrations of individual and total biliary lipids. Despite evidence of stasis in prairie dogs maintained on TPN, bile was unsaturated, and gallbladder absorption was not appreciably changed. In contrast, cholesterol-fed animals had cholesterol supersaturated bile, gallbladder stasis, and altered gallbladder absorption, as manifested by a significant change in the ratio of gallbladder to hepatic bile concentrations of individual and total biliary bile lipids. These data suggest that both cholesterol saturated bile and gallbladder stasis, and not stasis alone, are essential in promoting the enhanced gallbladder absorption, which had previously been observed during early cholesterol gallstone formation.
AB - Cholesterol saturated bile and gallbladder stasis are important factors in the pathogenesis of cholesterol gallstones. The degree to which either or both of these factors affect gallbladder transport of fluid remains obscure. The authors tested the hypothesis that both cholesterol saturated bile and gallbladder stasis, and not stasis alone, promoters gallbladder fluid absorption. Prairie dogs were maintained for 2 weeks on either a control chow, total parenteral nutrition (TPN), or a 1.2% cholesterol enriched chow. The bile acid pool was labeled with 14C-cholic acid and indexes for cholesterol saturation (CSI) and gallbladder stasis (Rsa) were determined. Fluid transport was indirectly measured by calculating the ratio of gallbladder to hepatic bile concentrations of individual and total biliary lipids. Despite evidence of stasis in prairie dogs maintained on TPN, bile was unsaturated, and gallbladder absorption was not appreciably changed. In contrast, cholesterol-fed animals had cholesterol supersaturated bile, gallbladder stasis, and altered gallbladder absorption, as manifested by a significant change in the ratio of gallbladder to hepatic bile concentrations of individual and total biliary bile lipids. These data suggest that both cholesterol saturated bile and gallbladder stasis, and not stasis alone, are essential in promoting the enhanced gallbladder absorption, which had previously been observed during early cholesterol gallstone formation.
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U2 - 10.1097/00000441-198608000-00002
DO - 10.1097/00000441-198608000-00002
M3 - Article
C2 - 3089012
AN - SCOPUS:0022905491
SN - 0002-9629
VL - 292
SP - 75
EP - 80
JO - American Journal of the Medical Sciences
JF - American Journal of the Medical Sciences
IS - 2
ER -