Enhanced external counterpulsation treatment attenuate the injury of brain dog model of cardiac arrest

Rong Liu, Xin Li, Chun Lin Hu, Li Jiang, Gang Dai, Ming Zhe Feng, Gui Fu Wu, Ying Qing Li, Xiao Xing Liao

Research output: Contribution to journalArticle

Abstract

Objective To investigate the therapeutic effects of enhanced external counterpulsation (EECP) on cerebral edema and cerebral blood flow perfusion with MRI following cardiac arrest (CA) and on successful return of spontaneous circulation (ROSC) by cardiopulmonary resuscitation (CPR) in dogs. Methods Sixteen beagle dogs were induced CA with alternating current on epicardium, then were randomly ( random number) divided into the EECP and control group after successful ROSC. MR scanning brain of all animals was carried out by diffusion-weighted imaging (DWI) and perfusion weighted imaging (PWI) before CA and on the first, second and third days after ROSC. Blood pressure, right common carotid artery flow, and intracranial microcirculation perfusion were measured. Results There were no significant differences in mean artery pressure at all intervals between two groups (P >0. 05). There was significant increase in right common carotid artery blood flow and intracranial microcirculation of dogs in EECP group compared with the control group (P <0. 05). Apparent diffusion coefficients (ADC) of water molecule on the first and third days after ROSC were significantly higher in the EECP group than those in the control group (P <0. 05). Ratios of post-ROSC relative cerebral blood flow (RCBF) /original cerebral blood flow were higher in the EECP group than those in the control group on the first, second and third days after ROSC (P <0. 05 ). Conclusions EECP treatment could improve cerebral blood flow perfusion and relieve ischemic cerebral edema, alleviating brain injury in dogs following CA and successful ROSC.

Original languageEnglish (US)
Pages (from-to)1215-1220
Number of pages6
JournalChinese Journal of Emergency Medicine
Volume21
Issue number11
DOIs
StatePublished - Nov 10 2012
Externally publishedYes

Fingerprint

Counterpulsation
Cerebrovascular Circulation
Heart Arrest
Brain Injuries
Dogs
Control Groups
Perfusion
Common Carotid Artery
Brain Edema
Microcirculation
Therapeutics
Induced Heart Arrest
Perfusion Imaging
Pericardium
Cardiopulmonary Resuscitation
Therapeutic Uses
Arteries
Blood Pressure
Pressure
Water

Keywords

  • Cardiac arrest
  • Cardiopulmonary cerebral resuscitation
  • Dog
  • Enhanced external counterpulsation
  • Magnetic resonance imaging
  • Microcirculation

ASJC Scopus subject areas

  • Emergency Medicine
  • Emergency

Cite this

Enhanced external counterpulsation treatment attenuate the injury of brain dog model of cardiac arrest. / Liu, Rong; Li, Xin; Hu, Chun Lin; Jiang, Li; Dai, Gang; Feng, Ming Zhe; Wu, Gui Fu; Li, Ying Qing; Liao, Xiao Xing.

In: Chinese Journal of Emergency Medicine, Vol. 21, No. 11, 10.11.2012, p. 1215-1220.

Research output: Contribution to journalArticle

Liu, Rong ; Li, Xin ; Hu, Chun Lin ; Jiang, Li ; Dai, Gang ; Feng, Ming Zhe ; Wu, Gui Fu ; Li, Ying Qing ; Liao, Xiao Xing. / Enhanced external counterpulsation treatment attenuate the injury of brain dog model of cardiac arrest. In: Chinese Journal of Emergency Medicine. 2012 ; Vol. 21, No. 11. pp. 1215-1220.
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abstract = "Objective To investigate the therapeutic effects of enhanced external counterpulsation (EECP) on cerebral edema and cerebral blood flow perfusion with MRI following cardiac arrest (CA) and on successful return of spontaneous circulation (ROSC) by cardiopulmonary resuscitation (CPR) in dogs. Methods Sixteen beagle dogs were induced CA with alternating current on epicardium, then were randomly ( random number) divided into the EECP and control group after successful ROSC. MR scanning brain of all animals was carried out by diffusion-weighted imaging (DWI) and perfusion weighted imaging (PWI) before CA and on the first, second and third days after ROSC. Blood pressure, right common carotid artery flow, and intracranial microcirculation perfusion were measured. Results There were no significant differences in mean artery pressure at all intervals between two groups (P >0. 05). There was significant increase in right common carotid artery blood flow and intracranial microcirculation of dogs in EECP group compared with the control group (P <0. 05). Apparent diffusion coefficients (ADC) of water molecule on the first and third days after ROSC were significantly higher in the EECP group than those in the control group (P <0. 05). Ratios of post-ROSC relative cerebral blood flow (RCBF) /original cerebral blood flow were higher in the EECP group than those in the control group on the first, second and third days after ROSC (P <0. 05 ). Conclusions EECP treatment could improve cerebral blood flow perfusion and relieve ischemic cerebral edema, alleviating brain injury in dogs following CA and successful ROSC.",
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AU - Feng, Ming Zhe

AU - Wu, Gui Fu

AU - Li, Ying Qing

AU - Liao, Xiao Xing

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N2 - Objective To investigate the therapeutic effects of enhanced external counterpulsation (EECP) on cerebral edema and cerebral blood flow perfusion with MRI following cardiac arrest (CA) and on successful return of spontaneous circulation (ROSC) by cardiopulmonary resuscitation (CPR) in dogs. Methods Sixteen beagle dogs were induced CA with alternating current on epicardium, then were randomly ( random number) divided into the EECP and control group after successful ROSC. MR scanning brain of all animals was carried out by diffusion-weighted imaging (DWI) and perfusion weighted imaging (PWI) before CA and on the first, second and third days after ROSC. Blood pressure, right common carotid artery flow, and intracranial microcirculation perfusion were measured. Results There were no significant differences in mean artery pressure at all intervals between two groups (P >0. 05). There was significant increase in right common carotid artery blood flow and intracranial microcirculation of dogs in EECP group compared with the control group (P <0. 05). Apparent diffusion coefficients (ADC) of water molecule on the first and third days after ROSC were significantly higher in the EECP group than those in the control group (P <0. 05). Ratios of post-ROSC relative cerebral blood flow (RCBF) /original cerebral blood flow were higher in the EECP group than those in the control group on the first, second and third days after ROSC (P <0. 05 ). Conclusions EECP treatment could improve cerebral blood flow perfusion and relieve ischemic cerebral edema, alleviating brain injury in dogs following CA and successful ROSC.

AB - Objective To investigate the therapeutic effects of enhanced external counterpulsation (EECP) on cerebral edema and cerebral blood flow perfusion with MRI following cardiac arrest (CA) and on successful return of spontaneous circulation (ROSC) by cardiopulmonary resuscitation (CPR) in dogs. Methods Sixteen beagle dogs were induced CA with alternating current on epicardium, then were randomly ( random number) divided into the EECP and control group after successful ROSC. MR scanning brain of all animals was carried out by diffusion-weighted imaging (DWI) and perfusion weighted imaging (PWI) before CA and on the first, second and third days after ROSC. Blood pressure, right common carotid artery flow, and intracranial microcirculation perfusion were measured. Results There were no significant differences in mean artery pressure at all intervals between two groups (P >0. 05). There was significant increase in right common carotid artery blood flow and intracranial microcirculation of dogs in EECP group compared with the control group (P <0. 05). Apparent diffusion coefficients (ADC) of water molecule on the first and third days after ROSC were significantly higher in the EECP group than those in the control group (P <0. 05). Ratios of post-ROSC relative cerebral blood flow (RCBF) /original cerebral blood flow were higher in the EECP group than those in the control group on the first, second and third days after ROSC (P <0. 05 ). Conclusions EECP treatment could improve cerebral blood flow perfusion and relieve ischemic cerebral edema, alleviating brain injury in dogs following CA and successful ROSC.

KW - Cardiac arrest

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