Enhanced discrimination of calcified and soft arterial plaques using computed tomography with a multi-energy-Window photon counting X-ray detector

Xiaolan Wang, Jingyan Xu, Katsuyuki Taguchi, Eric C. Frey, Bradley E. Patt, Douglas J. Wagenaar

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This work aims at discriminating between soft and calcified coronary artery plaques using microCT with a multi-energywindow photon counting X-ray detector (PCXD). We have previously investigated a solid state X-ray detector which has the capability to count individual photons in different energy windows. The data from these energy windows may be treated as multiple simultaneous X-ray acquisitions within non-overlapping energy windows that can provide additional information about tissue differences. In this work, we simulated a photon counting detector with five energy windows. We investigated two approaches for using the energy information provided by this detector. First, we applied energy weighting to the reconstruction from different energy windows to improve the signal-to-noise ratio between calcified and soft plaques. This resulted in a significant improvement in the signal-to-noise ratio. Second, we applied the basis material decomposition method to discriminate coronary artery plaques based on their calcium content. The results were compared with those obtained using dual-kVp material decomposition. We observed significantly improved contrast-to-noise ratios for the PCXD-based approaches

Original languageEnglish (US)
Title of host publicationMedical Imaging 2009
Subtitle of host publicationPhysics of Medical Imaging
DOIs
StatePublished - Jun 15 2009
EventMedical Imaging 2009: Physics of Medical Imaging - Lake Buena Vista, FL, United States
Duration: Feb 9 2009Feb 12 2009

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume7258
ISSN (Print)1605-7422

Other

OtherMedical Imaging 2009: Physics of Medical Imaging
CountryUnited States
CityLake Buena Vista, FL
Period2/9/092/12/09

Keywords

  • Basis material decomposition
  • Energy weighting
  • Multi-energy-window photon counting X-ray detector

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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    Wang, X., Xu, J., Taguchi, K., Frey, E. C., Patt, B. E., & Wagenaar, D. J. (2009). Enhanced discrimination of calcified and soft arterial plaques using computed tomography with a multi-energy-Window photon counting X-ray detector. In Medical Imaging 2009: Physics of Medical Imaging [72583W] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 7258). https://doi.org/10.1117/12.813877