The chronic administration of chlorphentermine to rats resulted in the appearance of enlarged, foamy alveolar macrophages (AMs) m the alveoli of the lungs. Circulating polymorphonuclear leukocytes (PMNs) from treated rats did not show a change in size. When challenged with unopsonized zymosan, the chemiluminescence (CL) of AMs from treated rats was enhanced with the peak response occurring later than with control AMs. Opsonization of the zymosan led to a further increase in CL from the foamy AMs while having no effect with control AMs. PMNs from treated rats also gave an enhanced CL response when compared to PMNs from control rats.
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