Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma

Isao Okayasu, Makoto Saegusa, Mutsunori Fujiwara, Yoshihito Hara, Noel R. Rose

Research output: Contribution to journalArticle

Abstract

For the analysis of cellular proliferative activity and cell death in thyroid diseases, the Ki-67 labeling index, bcl-2 protein expression and cell death of follicular epithelia by immunohistochemistry and in situ DNA nick-end labeling methods were evaluated in normal thyroid tissues as well as in surgical specimens from cases of Hashimoto's disease (16 cases), focal lymphocytic thyroiditis (13 cases), Graves' disease (15 cases), follicular adenoma (20 cases) and papillary carcinoma (43 cases). Cellular proliferative activity and cell death were both enhanced in cases of thyroiditis, including Hashimoto's disease and focal lymphocytic thyroiditis. Thyroids from patients with follicular adenoma and papillary carcinoma also showed increased cellular proliferative activity and cell death. In addition, predominant high cellularity and partial loss of bcl-2 protein expression in papillary carcinoma suggested that the overgrowth and dedifferentiation were associated with malignancy.

Original languageEnglish (US)
Pages (from-to)746-752
Number of pages7
JournalJournal of Cancer Research and Clinical Oncology
Volume121
Issue number12
DOIs
StatePublished - Dec 1995

Fingerprint

Papillary Carcinoma
Cell Death
Autoimmune Thyroiditis
Hashimoto Disease
Adenoma
Thyroid Gland
Single-Stranded DNA Breaks
Thyroiditis
Graves Disease
Thyroid Diseases
In Situ Nick-End Labeling
Proteins
Epithelium
Immunohistochemistry
Papillary Thyroid cancer
Chronic Thyroiditis
Neoplasms

Keywords

  • Apoptosis bcl-2
  • Cell death
  • Cell proliferation
  • Cellularity
  • Ki-67
  • Papillary carcinoma
  • Thyroiditis

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma. / Okayasu, Isao; Saegusa, Makoto; Fujiwara, Mutsunori; Hara, Yoshihito; Rose, Noel R.

In: Journal of Cancer Research and Clinical Oncology, Vol. 121, No. 12, 12.1995, p. 746-752.

Research output: Contribution to journalArticle

Okayasu, Isao ; Saegusa, Makoto ; Fujiwara, Mutsunori ; Hara, Yoshihito ; Rose, Noel R. / Enhanced cellular proliferative activity and cell death in chronic thyroiditis and thyroid papillary carcinoma. In: Journal of Cancer Research and Clinical Oncology. 1995 ; Vol. 121, No. 12. pp. 746-752.
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