Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates

R. Sanchez-Pernaute, J. Q. Wang, D. Kuruppu, L. Cao, W. Tueckmantel, A. Kozikowski, O. Isacson, A. L. Brownell

Research output: Contribution to journalArticle

Abstract

The interplay between dopamine and glutamate in the basal ganglia regulates critical aspects of motor learning and behavior. Metabotropic glutamate receptors (mGluR) are increasingly regarded as key modulators of neuroadaptation in these circuits, in normal and disease conditions. Using PET, we demonstrate a significant upregulation of mGluR type 5 in the striatum of MPTP-lesioned, parkinsonian primates, providing the basis for therapeutic exploration of mGluR5 antagonists in Parkinson disease.

Original languageEnglish (US)
Pages (from-to)248-251
Number of pages4
JournalNeuroImage
Volume42
Issue number1
DOIs
StatePublished - Aug 1 2008

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ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience

Cite this

Sanchez-Pernaute, R., Wang, J. Q., Kuruppu, D., Cao, L., Tueckmantel, W., Kozikowski, A., Isacson, O., & Brownell, A. L. (2008). Enhanced binding of metabotropic glutamate receptor type 5 (mGluR5) PET tracers in the brain of parkinsonian primates. NeuroImage, 42(1), 248-251. https://doi.org/10.1016/j.neuroimage.2008.04.170