Enhanced adhesion of anti-E-selectin biodegradable nanoparticles to Tnf-A activated endothelium in vitro and in vivo

Harshad S. Sakhalkar, Jie Fu, Sudhir P. Deosarkar, Xiaoyan Zou, Mark Christman, Justin S Hanes, David T. Kurjiaka, Douglas J. Goetz

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The expression of certain endothelial cell adhesion molecules (ECAMs), e.g. E-selectin, has been shown to be up-regulated at sites of pathological inflammation. As demonstrated by our recent publications (Sakhalkar et al., PNAS, 2003 and FASEB J., 2005), this local upregulation of ECAMs can be exploited to target micron sized PEGylated biodegradable particles to inflamed tissue. We term these particles leukocyte - endothelial cell adhesive particles (LEAPs). Since micron sized particles cannot be endocytosed, our laboratories sought to develop smaller (

Original languageEnglish (US)
Title of host publicationAIChE Annual Meeting, Conference Proceedings
Pages14302
Number of pages1
Publication statusPublished - 2005
Externally publishedYes
Event05AIChE: 2005 AIChE Annual Meeting and Fall Showcase - Cincinnati, OH, United States
Duration: Oct 30 2005Nov 4 2005

Other

Other05AIChE: 2005 AIChE Annual Meeting and Fall Showcase
CountryUnited States
CityCincinnati, OH
Period10/30/0511/4/05

    Fingerprint

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Sakhalkar, H. S., Fu, J., Deosarkar, S. P., Zou, X., Christman, M., Hanes, J. S., ... Goetz, D. J. (2005). Enhanced adhesion of anti-E-selectin biodegradable nanoparticles to Tnf-A activated endothelium in vitro and in vivo. In AIChE Annual Meeting, Conference Proceedings (pp. 14302)