Engineering Microphysiological Immune System Responses on Chips

Chris P. Miller, Woojung Shin, Eun Hyun Ahn, Hyun Jung Kim, Deok Ho Kim

Research output: Contribution to journalReview articlepeer-review


Tissues- and organs-on-chips are microphysiological systems (MPSs) that model the architectural and functional complexity of human tissues and organs that is lacking in conventional cell monolayer cultures. While substantial progress has been made in a variety of tissues and organs, chips recapitulating immune responses have not advanced as rapidly. This review discusses recent progress in MPSs for the investigation of immune responses. To illustrate recent developments, we focus on two cases in point: immunocompetent tumor microenvironment-on-a-chip devices that incorporate stromal and immune cell components and pathomimetic modeling of human mucosal immunity and inflammatory crosstalk. More broadly, we discuss the development of systems immunology-on-a-chip devices that integrate microfluidic engineering approaches with high-throughput omics measurements and emerging immunological applications of MPSs.

Original languageEnglish (US)
Pages (from-to)857-872
Number of pages16
JournalTrends in Biotechnology
Issue number8
StatePublished - Aug 2020


  • engineering immune system responses
  • immune system-on-a-chip
  • intestinal inflammation
  • microphysiological systems
  • systems immunology
  • tumor immune microenvironment

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering


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