@article{8106d3d4a3e14e8fa21b158233ed8f6c,
title = "Engineering Heart Morphogenesis",
abstract = "Recent advances in stem cell biology and tissue engineering have laid the groundwork for building complex tissues in a dish. We propose that these technologies are ready for a new challenge: recapitulating cardiac morphogenesis in vitro. In development, the heart transforms from a simple linear tube to a four-chambered organ through a complex process called looping. Here, we re-examine heart tube looping through the lens of an engineer and argue that the linear heart tube is an advantageous starting point for tissue engineering. We summarize the structures, signaling pathways, and stresses in the looping heart, and evaluate approaches that could be used to build a linear heart tube and guide it through the process of looping.",
keywords = "biomaterials, heart tube looping, mechanobiology, organogenesis, stem cells, tissue engineering",
author = "Mandrycky, {Christian J.} and Williams, {Nisa P.} and Ivan Batalov and Danny El-Nachef and {de Bakker}, {Bernadette S.} and Jennifer Davis and Kim, {Deok Ho} and DeForest, {Cole A.} and Ying Zheng and Stevens, {Kelly R.} and Sniadecki, {Nathan J.}",
note = "Funding Information: This work was supported by a generous donation from Gree Real Estate , as well as additional awards: NIH 1F31HL145809-01A1 (to N.P.W.), NIH F32HL143851 (to D.E.), NIH HL141187 and HL142624 (to J.D.), NIH R01HL146436, R01HL135143 and UG3 EB028094 (to D.H.K.), NSF CAREER Award DMR 1652141 (to C.A.D.), NIH R01HL141570 (to Y.Z.), NIH DP2HL137188 (to K.R.S.), and NSF CBET-1509106 and CMMI-1661730, NIH EB028094 (to N.J.S.). We also acknowledge the De Snoo – van {\textquoteright}t Hoogerhuijs Foundation for supporting this work. We thank Jaco Hagoort for assisting in the creation of the 3D-rendered images of the human heart tube used throughout this manuscript. Publisher Copyright: {\textcopyright} 2020 Elsevier Ltd",
year = "2020",
month = aug,
doi = "10.1016/j.tibtech.2020.01.006",
language = "English (US)",
volume = "38",
pages = "835--845",
journal = "Trends in Biotechnology",
issn = "0167-7799",
publisher = "Elsevier Limited",
number = "8",
}