Engineering custom-designed osteochondral tissue grafts

Warren L Grayson, Pen Hsiu Grace Chao, Darja Marolt, David L. Kaplan, Gordana Vunjak-Novakovic

Research output: Contribution to journalArticle

Abstract

Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).

Original languageEnglish (US)
Pages (from-to)181-189
Number of pages9
JournalTrends in Biotechnology
Volume26
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Grafts
Tissue
Transplants
Joints
Repair
Bearings (structural)
Weight-Bearing
Biocompatible Materials
Bioreactors
Tissue Engineering
Osteoarthritis
Regeneration
Tissue engineering
Biomaterials
Scaffolds
Cells
Research
Population

ASJC Scopus subject areas

  • Bioengineering

Cite this

Grayson, W. L., Chao, P. H. G., Marolt, D., Kaplan, D. L., & Vunjak-Novakovic, G. (2008). Engineering custom-designed osteochondral tissue grafts. Trends in Biotechnology, 26(4), 181-189. https://doi.org/10.1016/j.tibtech.2007.12.009

Engineering custom-designed osteochondral tissue grafts. / Grayson, Warren L; Chao, Pen Hsiu Grace; Marolt, Darja; Kaplan, David L.; Vunjak-Novakovic, Gordana.

In: Trends in Biotechnology, Vol. 26, No. 4, 04.2008, p. 181-189.

Research output: Contribution to journalArticle

Grayson, WL, Chao, PHG, Marolt, D, Kaplan, DL & Vunjak-Novakovic, G 2008, 'Engineering custom-designed osteochondral tissue grafts', Trends in Biotechnology, vol. 26, no. 4, pp. 181-189. https://doi.org/10.1016/j.tibtech.2007.12.009
Grayson, Warren L ; Chao, Pen Hsiu Grace ; Marolt, Darja ; Kaplan, David L. ; Vunjak-Novakovic, Gordana. / Engineering custom-designed osteochondral tissue grafts. In: Trends in Biotechnology. 2008 ; Vol. 26, No. 4. pp. 181-189.
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