TY - JOUR
T1 - Engineering custom-designed osteochondral tissue grafts
AU - Grayson, Warren L.
AU - Chao, Pen Hsiu Grace
AU - Marolt, Darja
AU - Kaplan, David L.
AU - Vunjak-Novakovic, Gordana
N1 - Funding Information:
Tissue engineering work in our laboratories has been supported by the National Institutes of Health (DE16525–01, HL076485 to G.V.N., EB002520 to G.V.N. and D.L.K.) and fellowships from the Arthritis Foundation (P.G.C.), Mandl Foundation (W.L.G.) and New York Stem Cell Foundation (D.M.).
PY - 2008/4
Y1 - 2008/4
N2 - Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).
AB - Tissue engineering is expected to help us outlive the failure of our organs by enabling the creation of tissue substitutes capable of fully restoring the original tissue function. Degenerative joint disease, which affects one-fifth of the US population and is the country's leading cause of disability, drives current research of actively growing, functional tissue grafts for joint repair. Toward this goal, living cells are used in conjunction with biomaterial scaffolds (serving as instructive templates for tissue development) and bioreactors (providing environmental control and molecular and physical regulatory signals). In this review, we discuss the requirements for engineering customized, anatomically-shaped, stratified grafts for joint repair and the challenges of designing these grafts to provide immediate functionality (load bearing, structural support) and long-term regeneration (maturation, integration, remodeling).
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U2 - 10.1016/j.tibtech.2007.12.009
DO - 10.1016/j.tibtech.2007.12.009
M3 - Review article
C2 - 18299159
AN - SCOPUS:40849137427
SN - 0167-7799
VL - 26
SP - 181
EP - 189
JO - Trends in Biotechnology
JF - Trends in Biotechnology
IS - 4
ER -