Engineering 3D skeletal muscle primed for neuromuscular regeneration following volumetric muscle loss

Jordana Gilbert-Honick, Kathryn Rae Wagner, Hai Quan Mao, Warren L Grayson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Volumetric muscle loss (VML) is a skeletal muscle defect that overwhelms native regenerative capabilities. Current treatments are limited and fail to fully recover lost function. Previous tissue engineered muscle constructs have had varied success but remain limited in their ability to encourage neuromuscular regeneration. Others have shown that exercise encourages neural infiltration 1 and that the protein agrin induces acetylcholine receptor (AChR) clustering in myoblasts 2 . In the current study we have assessed the separate effects of exercise post-VML on neural regeneration and of agrin application (soluble and chemically tethered) on AChR clustering in our constructs, and will evaluate their synergistic effects in ongoing studies (Fig. 1).

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

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ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Cite this

Gilbert-Honick, J., Wagner, K. R., Mao, H. Q., & Grayson, W. L. (2019). Engineering 3D skeletal muscle primed for neuromuscular regeneration following volumetric muscle loss. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.