Endurance training in the spontaneously hypertensive rat conversion of pathological into physiological cardiac hypertrophy

Carolina D. Garciarena, Oscar A. Pinilla, Mariela B. Nolly, Ruben P. Laguens, Eduardo M. Escudero, Horacio E. Cingolani, Irene L. Ennis

Research output: Contribution to journalArticle

Abstract

The effect of endurance training (swimming 90 min/d for 5 days a week for 60 days) on cardiac hypertrophy was investigated in the spontaneously hypertensive rat (SHR). Sedentary SHRs (SHR-Cs) and normotensive Wistar rats were used as controls. Exercise training enhanced myocardial hypertrophy assessed by left ventricular weight/tibial length (228±7 versus 251 ±5 mg/cm in SHR-Cs and exercised SHRs [SHR-Es], respectively). Myocyte cross-sectional area increased ≈40%, collagen volume fraction decreased ≈50%, and capillary density increased ≈45% in SHR-Es compared with SHR-Cs. The mRNA abundance of atrial natriuretic factor and myosin light chain 2 was decreased by the swimming routine (100± 19% versus 41 ± 10% and 100±8% versus 61 ±9% for atrial natriuretic factor and myosin light chain 2 in SHR-Cs and SHR-Es, respectively). The expression of sarcoplasmic reticulum Ca2+ pump was significantly augmented, whereas that of Na+/Ca2+ exchanger was unchanged (93±7% versus 167±8% and 158±13% versus 157±7%, sarcoplasmic reticulum Ca2+ pump and Na+/Ca2+ exchanger in SHR-Cs and SHR-Es, respectively; P

Original languageEnglish (US)
Pages (from-to)708-714
Number of pages7
JournalHypertension
Volume53
Issue number4
DOIs
StatePublished - Apr 2009
Externally publishedYes

Fingerprint

Cardiomegaly
Inbred SHR Rats
Atrial Myosins
Sarcoplasmic Reticulum
Atrial Natriuretic Factor
Left Ventricular Hypertrophy
Muscle Cells
Wistar Rats
Collagen
Exercise
Weights and Measures
Messenger RNA

Keywords

  • Apoptosis
  • Calcium handling
  • Cardiac hypertrophy
  • Exercise training
  • Hypertension
  • Signaling pathways

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Garciarena, C. D., Pinilla, O. A., Nolly, M. B., Laguens, R. P., Escudero, E. M., Cingolani, H. E., & Ennis, I. L. (2009). Endurance training in the spontaneously hypertensive rat conversion of pathological into physiological cardiac hypertrophy. Hypertension, 53(4), 708-714. https://doi.org/10.1161/HYPERTENSIONAHA.108.126805

Endurance training in the spontaneously hypertensive rat conversion of pathological into physiological cardiac hypertrophy. / Garciarena, Carolina D.; Pinilla, Oscar A.; Nolly, Mariela B.; Laguens, Ruben P.; Escudero, Eduardo M.; Cingolani, Horacio E.; Ennis, Irene L.

In: Hypertension, Vol. 53, No. 4, 04.2009, p. 708-714.

Research output: Contribution to journalArticle

Garciarena, CD, Pinilla, OA, Nolly, MB, Laguens, RP, Escudero, EM, Cingolani, HE & Ennis, IL 2009, 'Endurance training in the spontaneously hypertensive rat conversion of pathological into physiological cardiac hypertrophy', Hypertension, vol. 53, no. 4, pp. 708-714. https://doi.org/10.1161/HYPERTENSIONAHA.108.126805
Garciarena, Carolina D. ; Pinilla, Oscar A. ; Nolly, Mariela B. ; Laguens, Ruben P. ; Escudero, Eduardo M. ; Cingolani, Horacio E. ; Ennis, Irene L. / Endurance training in the spontaneously hypertensive rat conversion of pathological into physiological cardiac hypertrophy. In: Hypertension. 2009 ; Vol. 53, No. 4. pp. 708-714.
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