Endotoxemia-mediated activation of acetyltransferase P300 impairs insulin signaling in obesity

Medicine & Life Sciences

• p300-CBP-associated factor 89%
• Endotoxemia 68%
• Lipopolysaccharides 48%
• Insulin Resistance 46%
• Endoplasmic Reticulum Stress 42%
• Obesity 39%
• Insulin 38%
• Obese Mice 23%
• Insulin Receptor 21%
• Heat-Shock Proteins 19%
• High Fat Diet 18%
• Hyperglycemia 17%
• Permeability 16%
• Hepatocytes 15%
• Cytoplasm 15%
• Transcription Factors 14%
• Diet 12%
• Pharmacology 12%
• Glucose 11%
• Inflammation 11%
• Therapeutics 6%

Physics & Astronomy

• obesity 100%
• insulin 81%
• activation 44%
• diets 35%
• mice 35%
• endoplasmic reticulum 32%
• hyperglycemia 20%
• cytoplasm 13%
• fats 13%
• inhibitors 13%
• glucose 13%
• grade 10%
• induction 10%
• permeability 9%
• proteins 9%
• nuclei 7%
• sensors 6%
• sensitivity 6%

Chemical Compounds

• Insulin Derivative 57%
• Lipopolysaccharide 37%
• Resistance 14%
• Plasma Concentration 13%
• Permeability 9%
• Glucose 8%
• Protein 4%