Abstract
Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.
Original language | English (US) |
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Pages (from-to) | 14-22 |
Number of pages | 9 |
Journal | Asian Journal of Andrology |
Volume | 10 |
Issue number | 1 |
DOIs | |
State | Published - Jan 1 2008 |
Keywords
- Endothelial-specificgene
- Endothelialdys function
- Erectile dysfunction
- Gene therapy
ASJC Scopus subject areas
- Urology