Endothelium-specific gene and stem cell-based therapy for erectile dysfunction

Travis D. Strong, Milena A. Gebska, Arthur L. Burnett, Hunter C. Champion, Trinity J. Bivalacqua

Research output: Contribution to journalReview article

Abstract

Erectile dysfunction (ED) commonly results from endothelial dysfunction of the systemic vasculature. Although phosphodiesterase type 5 (PDE-5) inhibitors are effective at treating most cases of ED, they must be taken routinely and are ineffectual for a meaningful number of men. In recent years gene and stem cell-based therapies targeted at the penile endothelium have been gaining momentum in preclinical studies. These early studies reveal that gene and stem cell-based therapies may be both enduring and efficacious, and may eventually lead to a cure for ED. The following review will highlight our current understanding of endothelial-specific gene and stem cell-based therapies performed to date in a number of experimental animal models.

Original languageEnglish (US)
Pages (from-to)14-22
Number of pages9
JournalAsian Journal of Andrology
Volume10
Issue number1
DOIs
StatePublished - Jan 1 2008

Keywords

  • Endothelial-specificgene
  • Endothelialdys function
  • Erectile dysfunction
  • Gene therapy

ASJC Scopus subject areas

  • Urology

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