Endothelin-1 (ET-1) causes inhibition of delayed rectifier K⁺ (K_DR) current and constriction in human pulmonary artery (PA)

Medicine & Life Sciences

• Endothelin-1 72%
• Constriction 64%
• Pulmonary Artery 61%
• Protein Kinase C 18%
• Endothelin A Receptor Antagonists 14%
• Arteries 14%
• cyclo(Trp-Asp-Pro-Val-Leu) 13%
• Charybdotoxin 13%
• Tyrode's solution 13%
• Endothelin A Receptors 12%
• Endothelium-Dependent Relaxing Factors 12%
• 4-Aminopyridine 12%
• Staurosporine 11%
• Protein C Inhibitor 11%
• Bicarbonates 10%
• Patch-Clamp Techniques 10%
• Protein Kinase Inhibitors 10%
• Baths 9%
• Muscle Cells 8%
• Endothelium 8%
• Smooth Muscle Myocytes 8%
• Lung 5%

Chemical Compounds

• Endothelin-1 100%
• Endothelin A Receptor Antagonist 21%
• Intrapulmonary 20%
• BQ 123 20%
• Endothelium Dependent Relaxing Factor 18%
• Protein Kinase C Inhibitor 17%
• Staurosporine 16%
• 4-Aminopyridine 15%
• Depolarization 12%
• Tension 10%
• Protein 4%