Endothelial progenitor cells as putative targets for angiostatin

Hideaki Ito, Ilsa I. Rovira, Michael L. Bloom, Kazuyo Takeda, Victor J. Ferrans, Arshed A. Quyyumi, Toren Finkel

Research output: Contribution to journalArticlepeer-review

Abstract

Angiostatin, a product of the proteolytic cleavage of plasminogen, possesses potent antitumor and antiangiogenic properties in vivo. Studies with cultured endothelial cells suggest that under certain conditions, angiostatin inhibits the migration and proliferation of these cells or, alternatively, increases their rate of apoptosis. In general, the effects of angiostatin have been considerably less potent in vitro than in vivo. One potential explanation for this disparity is that the in vivo target of angiostatin is not the mature endothelial cell. Recently, evidence has accumulated to show that circulating endothelial progenitor cells (EPCs) contribute to neovascularization. In this study, we have isolated EPCs from human subjects and demonstrated that, in contrast to that of mature endothelial cells, the growth of EPCs is exquisitely sensitive to angiostatin. These results suggest that angiostatin and related compounds may exert their biological effects by inhibiting the contribution of EPCs to angiogenesis and not by altering the growth of mature endothelial cells.

Original languageEnglish (US)
Pages (from-to)5875-5877
Number of pages3
JournalCancer Research
Volume59
Issue number23
StatePublished - Dec 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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