Endothelial nitric oxide synthase regulation in female genital tract structures

Biljana Musicki, Tongyun Liu, Gwen A. Lagoda, Trinity Bivalacqua, Travis D. Strong, Arthur Burnett

Research output: Contribution to journalArticle

Abstract

Introduction. Female sexual arousal disorder (FSAD) is a major component of female sexual dysfunctions, affecting 25-70% of women. The mechanisms of FSAD are poorly understood. Estrogen contributes to the control of genital blood flow during the sexual response. Vascular effects of estrogen are mostly attributed to its regulation of endothelial nitric oxide (NO) production. However, the role of endothelial NO synthase (eNOS) and the mechanisms that regulate eNOS in female genital tract structures are largely unknown. Aim. To review available evidence of the mechanisms of eNOS regulation in female genital tract structures. Methods. This article reviews the literature that relates to the role of NO and eNOS in female sexual arousal and its modulation by estrogen. Main Outcome Measures. Association between female sexual arousal, NO, and eNOS. Results. The NO/cyclic guanosine monophosphate pathway is believed to have a primary role in the regulation of clitoral and vaginal blood flow, and smooth muscle relaxation during sexual arousal. Estrogen is critical for maintaining vaginal and clitoral blood flow and vaginal transudate production. Estrogen regulates eNOS by genomic mechanisms, involving augmented mRNA transcription and protein synthesis, and by non-genomic mechanisms, which occur without alterations in gene expression. However, limited studies have evaluated the physiological role of endothelial NO and the molecular mechanisms of eNOS regulation in the female genital tract. Conclusions. The effects of estrogen on increasing genital blood flow and smooth muscle relaxation have been attributed mostly to regulation of eNOS. However, the exact mechanisms of eNOS regulation in female genital tract structures and the molecular basis for the eNOS defect with aging and vascular diseases warrant further investigation. Musicki B, Liu T, Lagoda GA, Bivalacqua TJ, Strong TD, and Burnett AL. Endothelial nitric oxide synthase regulation in female genital tract structures.

Original languageEnglish (US)
Pages (from-to)247-253
Number of pages7
JournalJournal of Sexual Medicine
Volume6
Issue numberSUPPL. 3
DOIs
StatePublished - 2009

Fingerprint

Nitric Oxide Synthase Type III
Nitric Oxide Synthase
Estrogens
Nitric Oxide
Arousal
Psychological Sexual Dysfunctions
Muscle Relaxation
Smooth Muscle
Cyclic GMP
Exudates and Transudates
Molecular Structure
Vascular Diseases
Blood Vessels
Outcome Assessment (Health Care)
Gene Expression
Messenger RNA

Keywords

  • Caveolin
  • Clitoris
  • Female sexual arousal
  • Vagina

ASJC Scopus subject areas

  • Urology
  • Obstetrics and Gynecology
  • Reproductive Medicine

Cite this

Endothelial nitric oxide synthase regulation in female genital tract structures. / Musicki, Biljana; Liu, Tongyun; Lagoda, Gwen A.; Bivalacqua, Trinity; Strong, Travis D.; Burnett, Arthur.

In: Journal of Sexual Medicine, Vol. 6, No. SUPPL. 3, 2009, p. 247-253.

Research output: Contribution to journalArticle

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