Endothelial dysfunction in diabetic erectile dysfunction

Research output: Contribution to journalArticle

Abstract

Erectile dysfunction (ED) is highly prevalent in diabetes mellitus. Pathophysiological mechanisms underlying diabetes-associated ED are in large part due to endothelial dysfunction, which functionally refers to the inability of the endothelium to produce vasorelaxing messengers and to maintain vasodilation and vascular homeostasis. The precise mechanisms leading to endothelial dysfunction in the diabetic vasculature, including the penis, are not yet fully understood. Hyperglycemia affects endothelial nitric oxide synthase activity and nitric oxide production/bioavailability, nitric oxide-independent relaxing factors, oxidative stress, production and/or action of hormones, growth factors and/or cytokines, and generation and activity of opposing vasoconstrictors. Considering recent advances in the field of vascular biology and diabetes, the emphasis in this review is placed on the mechanisms of hyperglycemia-induced endothelial dysfunction in the pathophysiology of diabetes-associated ED.

Original languageEnglish (US)
Pages (from-to)129-138
Number of pages10
JournalInternational journal of impotence research : official journal of the International Society for Impotence Research
Volume19
Issue number2
DOIs
StatePublished - Mar 25 2007

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Erectile Dysfunction
Hyperglycemia
Blood Vessels
Nitric Oxide
Nitric Oxide Synthase Type III
Penis
Vasoconstrictor Agents
Vasodilation
Biological Availability
Endothelium
Intercellular Signaling Peptides and Proteins
Diabetes Mellitus
Oxidative Stress
Homeostasis
Hormones
Cytokines

Keywords

  • eNOS
  • Hyperglycemia
  • NO
  • NO-independent endothelial relaxing factors
  • Oxidative stress
  • RhoA/Rhokinase

ASJC Scopus subject areas

  • Urology

Cite this

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abstract = "Erectile dysfunction (ED) is highly prevalent in diabetes mellitus. Pathophysiological mechanisms underlying diabetes-associated ED are in large part due to endothelial dysfunction, which functionally refers to the inability of the endothelium to produce vasorelaxing messengers and to maintain vasodilation and vascular homeostasis. The precise mechanisms leading to endothelial dysfunction in the diabetic vasculature, including the penis, are not yet fully understood. Hyperglycemia affects endothelial nitric oxide synthase activity and nitric oxide production/bioavailability, nitric oxide-independent relaxing factors, oxidative stress, production and/or action of hormones, growth factors and/or cytokines, and generation and activity of opposing vasoconstrictors. Considering recent advances in the field of vascular biology and diabetes, the emphasis in this review is placed on the mechanisms of hyperglycemia-induced endothelial dysfunction in the pathophysiology of diabetes-associated ED.",
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