TY - JOUR
T1 - Endothelial dysfunction as a nexus for endothelial cell-cardiomyocyte miscommunication
AU - Leucker, Thorsten M.
AU - Jones, Steven P.
PY - 2014
Y1 - 2014
N2 - Most studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere "passive lining" or supportive role. In fact, EC contribute to a dynamic network regulating vascular tone, cardiac development, and repair. Two distinct EC types, vascular EC and epicardial EC, possess important structural and signaling properties within both the healthy and diseased myocardium. In this review, we address EC-CM interactions in mature, healthy myocardium, followed by a discussion of diseases characterized by EC dysfunction. Finally, we consider strategies to reverse EC-CM "miscommunication" to improve patients' outcomes in various cardiovascular diseases.
AB - Most studies of the heart focus on cardiomyocytes (CM) at the exclusion of other cell types such as myocardial endothelial cells (EC). Such mono-cellular approaches propagate the presumption that EC provide a mere "passive lining" or supportive role. In fact, EC contribute to a dynamic network regulating vascular tone, cardiac development, and repair. Two distinct EC types, vascular EC and epicardial EC, possess important structural and signaling properties within both the healthy and diseased myocardium. In this review, we address EC-CM interactions in mature, healthy myocardium, followed by a discussion of diseases characterized by EC dysfunction. Finally, we consider strategies to reverse EC-CM "miscommunication" to improve patients' outcomes in various cardiovascular diseases.
KW - Cardiomyocyte
KW - Cardiovascular disease
KW - Endothelial function
KW - Juxtacrine communication
KW - Paracrine factors
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U2 - 10.3389/fphys.2014.00328
DO - 10.3389/fphys.2014.00328
M3 - Article
AN - SCOPUS:84906501274
SN - 1664-042X
VL - 5 AUG
JO - Frontiers in Physiology
JF - Frontiers in Physiology
M1 - Article 328
ER -