Endothelial cells transformed by SV40 T antigen cause Kaposi's sarcomalike tumors in nude mice

Kathryn O'Connell, Gilles Landman, Evan Farmer, Michael A Edidin

Research output: Contribution to journalArticle

Abstract

Injection into nude mice of a well-differentiated SV40 T-antigen-transformed murine endothelial cell (EC) line results in widespread invasive tumors confined to connective tissues. The tumors, which do not metastasize, consist of both host-derived cells and transformed EC, displaying histologic features typical of Kaposi's sarcoma (KS). Although the EC is believed to be the cell of origin in KS, this has not been proven and is the subject of debate. The unusual tumorigenicity of this transformed cell suggests that EC-specific gene products induced by SV40 T antigen may contribute to tumorigenesis by autocrine growth stimulation and recruitment of host cells. KS-like tumors may be the result of EC alteration by any virus that induces relevant EC-derived cytokines.

Original languageEnglish (US)
Pages (from-to)743-749
Number of pages7
JournalAmerican Journal of Pathology
Volume139
Issue number4
StatePublished - Oct 1991

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Polyomavirus Transforming Antigens
Nude Mice
Endothelial Cells
Kaposi's Sarcoma
Neoplasms
Connective Tissue
Carcinogenesis
Cytokines
Viruses
Cell Line
Injections
Growth
Genes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Endothelial cells transformed by SV40 T antigen cause Kaposi's sarcomalike tumors in nude mice. / O'Connell, Kathryn; Landman, Gilles; Farmer, Evan; Edidin, Michael A.

In: American Journal of Pathology, Vol. 139, No. 4, 10.1991, p. 743-749.

Research output: Contribution to journalArticle

O'Connell, Kathryn ; Landman, Gilles ; Farmer, Evan ; Edidin, Michael A. / Endothelial cells transformed by SV40 T antigen cause Kaposi's sarcomalike tumors in nude mice. In: American Journal of Pathology. 1991 ; Vol. 139, No. 4. pp. 743-749.
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