Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Zack Z. Wang, Patrick Au, Tong Chen, Ying Shao, Laurence M. Daheron, Hao Bai, Melanie Arzigian, Dai Fukumura, Rakesh K. Jain, David T. Scadden

Research output: Contribution to journalArticle

Abstract

We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.

Original languageEnglish (US)
Pages (from-to)317-318
Number of pages2
JournalNature biotechnology
Volume25
Issue number3
DOIs
StatePublished - Mar 1 2007

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ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology
  • Molecular Medicine
  • Biomedical Engineering

Cite this

Wang, Z. Z., Au, P., Chen, T., Shao, Y., Daheron, L. M., Bai, H., Arzigian, M., Fukumura, D., Jain, R. K., & Scadden, D. T. (2007). Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo. Nature biotechnology, 25(3), 317-318. https://doi.org/10.1038/nbt1287