Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Zack Z. Wang; Patrick Au; Tong Chen; Ying Shao; Laurence M. Daheron; Hao Bai; Melanie Arzigian; Dai Fukumura; Rakesh K. Jain; David T. Scadden

doi:10.1038/nbt1287

Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Zack Z. Wang, Patrick Au, Tong Chen, Ying Shao, Laurence M. Daheron, Hao Bai, Melanie Arzigian, Dai Fukumura, Rakesh K. Jain, David T. Scadden

Research output: Contribution to journal › Article › peer-review

242 Scopus citations

Abstract

We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.

Original language	English (US)
Pages (from-to)	317-318
Number of pages	2
Journal	Nature biotechnology
Volume	25
Issue number	3
DOIs	https://doi.org/10.1038/nbt1287
State	Published - Mar 2007
Externally published	Yes

ASJC Scopus subject areas

Biotechnology
Bioengineering
Applied Microbiology and Biotechnology
Molecular Medicine
Biomedical Engineering

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title = "Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo",

abstract = "We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.",

author = "Wang, {Zack Z.} and Patrick Au and Tong Chen and Ying Shao and Daheron, {Laurence M.} and Hao Bai and Melanie Arzigian and Dai Fukumura and Jain, {Rakesh K.} and Scadden, {David T.}",

note = "Funding Information: This study was partially supported by National Institutes of Health grants K01DK064696 (Z.W.), P20RR018789 (Z.W.), P01CA80124 (R.K.J., D.F.), R01CA96915 (D.F.) and R01CA115767 (R.K.J.) and the Harvard Stem Cell Institute.",

year = "2007",

month = mar,

doi = "10.1038/nbt1287",

language = "English (US)",

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AU - Wang, Zack Z.

AU - Au, Patrick

AU - Chen, Tong

AU - Shao, Ying

AU - Daheron, Laurence M.

AU - Bai, Hao

AU - Arzigian, Melanie

AU - Fukumura, Dai

AU - Jain, Rakesh K.

AU - Scadden, David T.

N1 - Funding Information: This study was partially supported by National Institutes of Health grants K01DK064696 (Z.W.), P20RR018789 (Z.W.), P01CA80124 (R.K.J., D.F.), R01CA96915 (D.F.) and R01CA115767 (R.K.J.) and the Harvard Stem Cell Institute.

PY - 2007/3

Y1 - 2007/3

N2 - We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.

AB - We describe the differentiation of human embryonic stem (hES) cells into endothelial cells using a scalable two-dimensional method that avoids an embryoid-body intermediate. After transplantation into severe combined immunodeficient (SCID) mice, the differentiated cells contributed to arborized blood vessels that integrated into the host circulatory system and served as blood conduits for 150 d.

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Endothelial cells derived from human embryonic stem cells form durable blood vessels in vivo

Abstract

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