Endothelial cell signaling and endothelial dysfunction

Nicholas Flavahan, P. M. Vanhoutte

Research output: Contribution to journalArticle

Abstract

Endothelial cells have an important protective role in maintaining the normal physiologic function of the vascular wall. When these cells become dysfunctional, they lose this protective influence and they actively promote pathophysiological changes within the blood vessel. This review will discuss some, of the extracellular signaling mechanisms employed by normal endothelial cells to exert a protective influence in the vascular wall and those signals generated by dysfunctional cells to promote the atherosclerotic process. It will also discuss the intracellular processes that regulate the release/expression of these signals and that control the transformation of this protective cell to one that promotes the development of vascular disease.

Original languageEnglish (US)
JournalAmerican Journal of Hypertension
Volume8
Issue number5 II SUPPL.
StatePublished - 1995

Fingerprint

Blood Vessels
Endothelial Cells
Vascular Diseases

Keywords

  • Endothelium
  • G-proteins
  • Hypercholesterolemia
  • Lipoproteins
  • Lysophosphatidylcholine
  • Nitric oxide

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Endothelial cell signaling and endothelial dysfunction. / Flavahan, Nicholas; Vanhoutte, P. M.

In: American Journal of Hypertension, Vol. 8, No. 5 II SUPPL., 1995.

Research output: Contribution to journalArticle

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