Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty

Jonathan H. Lass, Alan Sugar, Beth Ann Benetz, Roy W. Beck, Mariya Dontchev, Robin L. Gal, Craig Kollman, Robert Gross, Ellen Heck, Edward J. Holland, Mark J. Mannis, Irving Raber, Walter Stark, R. Doyle Stulting

Research output: Contribution to journalArticle

Abstract

Objective: To determine whether preoperative and/or postoperative central endothelial cell density (ECD) and its rate of decline postoperatively are predictive of graft failure caused by endothelial decompensation following penetrating keratoplasty to treat a moderate-risk condition, principally, Fuchs dystrophy or pseudophakic corneal edema. Methods: In a subset of Cornea Donor Study participants, a central reading center determined preoperative and postoperative ECD from available specular images for 17 grafts that failed because of endothelial decompensation and 483 grafts that did not fail. Results: Preoperative ECD was not predictive of graft failure caused by endothelial decompensation (P=.91). However, the 6-month ECD was predictive of subsequent failure (P2 or higher. After 5 years' follow-up, 40 of 277 participants (14%) with a clear graft had an ECD below 500 cells/mm2. Conclusions: Preoperative ECD is unrelated to graft failure from endothelial decompensation, whereas there is a strong correlation of ECD at 6 months with graft failure from endothelial decompensation. A graft can remain clear after 5 years even when the ECD is below 500 cells/mm2. Clinical Trial Registry: clinicaltrials.gov Identifier: NCT00006411.

Original languageEnglish (US)
Pages (from-to)63-69
Number of pages7
JournalArchives of Ophthalmology
Volume128
Issue number1
DOIs
StatePublished - Jan 2010

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Penetrating Keratoplasty
Endothelial Cells
Cell Count
Transplants
Fuchs' Endothelial Dystrophy
Corneal Edema
Cornea
Registries
Reading
Clinical Trials

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Lass, J. H., Sugar, A., Benetz, B. A., Beck, R. W., Dontchev, M., Gal, R. L., ... Stulting, R. D. (2010). Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty. Archives of Ophthalmology, 128(1), 63-69. https://doi.org/10.1001/archophthalmol.2010.128.63

Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty. / Lass, Jonathan H.; Sugar, Alan; Benetz, Beth Ann; Beck, Roy W.; Dontchev, Mariya; Gal, Robin L.; Kollman, Craig; Gross, Robert; Heck, Ellen; Holland, Edward J.; Mannis, Mark J.; Raber, Irving; Stark, Walter; Stulting, R. Doyle.

In: Archives of Ophthalmology, Vol. 128, No. 1, 01.2010, p. 63-69.

Research output: Contribution to journalArticle

Lass, JH, Sugar, A, Benetz, BA, Beck, RW, Dontchev, M, Gal, RL, Kollman, C, Gross, R, Heck, E, Holland, EJ, Mannis, MJ, Raber, I, Stark, W & Stulting, RD 2010, 'Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty', Archives of Ophthalmology, vol. 128, no. 1, pp. 63-69. https://doi.org/10.1001/archophthalmol.2010.128.63
Lass, Jonathan H. ; Sugar, Alan ; Benetz, Beth Ann ; Beck, Roy W. ; Dontchev, Mariya ; Gal, Robin L. ; Kollman, Craig ; Gross, Robert ; Heck, Ellen ; Holland, Edward J. ; Mannis, Mark J. ; Raber, Irving ; Stark, Walter ; Stulting, R. Doyle. / Endothelial cell density to predict endothelial graft failure after penetrating keratoplasty. In: Archives of Ophthalmology. 2010 ; Vol. 128, No. 1. pp. 63-69.
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AU - Gal, Robin L.

AU - Kollman, Craig

AU - Gross, Robert

AU - Heck, Ellen

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