Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma

Robert R. Freedman, Reda Girgis, Maureen D. Mayes

Research output: Contribution to journalArticle

Abstract

Objective. To investigate the involvement of endothelial and adrenergic mechanisms in patients with Raynaud's phenomenon (RP) and scleroderma. Methods. Ten patients with RP and scleroderma and 10 healthy volunteer controls were studied. Intraarterial methacholine, sodium nitroprusside, and clonidine were administered while bilateral finger blood flow was measured with venous occlusion plethysmography. Results. Compared to the controls, the patients showed diminished responses to methacholine, an endothelium dependent vasodilator, and to clonidine, an α2-adrenergic agonist. However, both groups showed similar responses to sodium nitroprusside, an endothelium independent vasodilator. Conclusion. The findings were consistent with previous histological evidence of endothelial damage in scleroderma blood vessels. Failure to release nitric oxide from vascular endothelium may play a role in RP in patients with scleroderma.

Original languageEnglish (US)
Pages (from-to)2386-2388
Number of pages3
JournalJournal of Rheumatology
Volume26
Issue number11
StatePublished - 1999
Externally publishedYes

Fingerprint

Raynaud Disease
Adrenergic Agents
Methacholine Chloride
Clonidine
Nitroprusside
Endothelium-Dependent Relaxing Factors
Adrenergic Agonists
Plethysmography
Vascular Endothelium
Vasodilator Agents
Fingers
Endothelium
Blood Vessels
Healthy Volunteers
Nitric Oxide

Keywords

  • Blood vessels
  • Endothelium
  • Raynaud's phenomenon
  • Scleroderma

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Freedman, R. R., Girgis, R., & Mayes, M. D. (1999). Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma. Journal of Rheumatology, 26(11), 2386-2388.

Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma. / Freedman, Robert R.; Girgis, Reda; Mayes, Maureen D.

In: Journal of Rheumatology, Vol. 26, No. 11, 1999, p. 2386-2388.

Research output: Contribution to journalArticle

Freedman, RR, Girgis, R & Mayes, MD 1999, 'Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma', Journal of Rheumatology, vol. 26, no. 11, pp. 2386-2388.
Freedman, Robert R. ; Girgis, Reda ; Mayes, Maureen D. / Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma. In: Journal of Rheumatology. 1999 ; Vol. 26, No. 11. pp. 2386-2388.
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