Abstract
Objective. To investigate the involvement of endothelial and adrenergic mechanisms in patients with Raynaud's phenomenon (RP) and scleroderma. Methods. Ten patients with RP and scleroderma and 10 healthy volunteer controls were studied. Intraarterial methacholine, sodium nitroprusside, and clonidine were administered while bilateral finger blood flow was measured with venous occlusion plethysmography. Results. Compared to the controls, the patients showed diminished responses to methacholine, an endothelium dependent vasodilator, and to clonidine, an α2-adrenergic agonist. However, both groups showed similar responses to sodium nitroprusside, an endothelium independent vasodilator. Conclusion. The findings were consistent with previous histological evidence of endothelial damage in scleroderma blood vessels. Failure to release nitric oxide from vascular endothelium may play a role in RP in patients with scleroderma.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2386-2388 |
| Number of pages | 3 |
| Journal | Journal of Rheumatology |
| Volume | 26 |
| Issue number | 11 |
| State | Published - 1999 |
| Externally published | Yes |
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Keywords
- Blood vessels
- Endothelium
- Raynaud's phenomenon
- Scleroderma
ASJC Scopus subject areas
- Rheumatology
- Immunology
Cite this
Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma. / Freedman, Robert R.; Girgis, Reda; Mayes, Maureen D.
In: Journal of Rheumatology, Vol. 26, No. 11, 1999, p. 2386-2388.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endothelial and adrenergic dysfunction in Raynaud's phenomenon and scleroderma
AU - Freedman, Robert R.
AU - Girgis, Reda
AU - Mayes, Maureen D.
PY - 1999
Y1 - 1999
N2 - Objective. To investigate the involvement of endothelial and adrenergic mechanisms in patients with Raynaud's phenomenon (RP) and scleroderma. Methods. Ten patients with RP and scleroderma and 10 healthy volunteer controls were studied. Intraarterial methacholine, sodium nitroprusside, and clonidine were administered while bilateral finger blood flow was measured with venous occlusion plethysmography. Results. Compared to the controls, the patients showed diminished responses to methacholine, an endothelium dependent vasodilator, and to clonidine, an α2-adrenergic agonist. However, both groups showed similar responses to sodium nitroprusside, an endothelium independent vasodilator. Conclusion. The findings were consistent with previous histological evidence of endothelial damage in scleroderma blood vessels. Failure to release nitric oxide from vascular endothelium may play a role in RP in patients with scleroderma.
AB - Objective. To investigate the involvement of endothelial and adrenergic mechanisms in patients with Raynaud's phenomenon (RP) and scleroderma. Methods. Ten patients with RP and scleroderma and 10 healthy volunteer controls were studied. Intraarterial methacholine, sodium nitroprusside, and clonidine were administered while bilateral finger blood flow was measured with venous occlusion plethysmography. Results. Compared to the controls, the patients showed diminished responses to methacholine, an endothelium dependent vasodilator, and to clonidine, an α2-adrenergic agonist. However, both groups showed similar responses to sodium nitroprusside, an endothelium independent vasodilator. Conclusion. The findings were consistent with previous histological evidence of endothelial damage in scleroderma blood vessels. Failure to release nitric oxide from vascular endothelium may play a role in RP in patients with scleroderma.
KW - Blood vessels
KW - Endothelium
KW - Raynaud's phenomenon
KW - Scleroderma
UR - http://www.scopus.com/inward/record.url?scp=0032730980&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032730980&partnerID=8YFLogxK
M3 - Article
VL - 26
SP - 2386
EP - 2388
JO - Journal of Rheumatology
JF - Journal of Rheumatology
SN - 0315-162X
IS - 11
ER -