Endoscopic treatment of vesicoureteral reflux using cross-linked bovine dermal collagen

To assess the efficacy of endoscopic treatment of vesicoureteral reflux (VUR) with cross-linked bovine collagen, 59 patients with grade I through V VUR were evaluated and treated. Follow-up consisted of a voiding cystourethrogram and renal ultrasound at 1 month and 1 year with urinalysis and urine culture. Repeat treatment was carried out in cases in which no resolution of the reflux was noted up to three times. The procedure was performed on an outpatient basis in 56 patients and was not associated with any major morbidity or mortality. Cure at 1 month was observed in 75% of ureters treated; cure persisted in 79% of these ureters at 1 year. The overall cure rate was 65% at 1 year. Given the simplicity of the procedure, its low complication rate, and overall success in the majority of patients, we feel that endoscopic treatment of VUR with cross-linked bovine dermal collagen is a safe and effective method and worthy of further study to enhance its efficacy.