Endoscopic therapy for GERD: Is the evidence for efficacy any stronger?

Pankaj Jay Pasricha, Binh V. Pham

Research output: Contribution to journalArticle

Abstract

Gastroesophageal reflux disease (GERD) is a common chronic medical disorder that has a significant impact on quality of life and afflicts millions of people worldwide. Therapy with either daily medications or surgical fundoplication, though highly effective for the majority of patients, is not without long-term shortcomings. The development of endoscopic antireflux therapies has been fueled by the hope of providing safe, effective, long-term symptomatic relief. Although several studies have been published, they are limited by small sample size, tack of adequate controls, and a highly selective patient population. However, it is clear that many, if not most, patients will continue to be on acid-suppressive therapy despite these procedures. Also, reports of postmarketing adverse effects emphasize the need for further scrutiny of the safety of these devices. This review will summarize the available evidence and provide tentative conclusions about the current and evolving role of endoscopic antireflux therapy.

Original languageEnglish (US)
Pages (from-to)59-68
Number of pages10
JournalCurrent Treatment Options in Gastroenterology
Volume9
Issue number1
DOIs
StatePublished - Feb 2006
Externally publishedYes

Fingerprint

Gastroesophageal Reflux
Protective Devices
Fundoplication
Therapeutics
Sample Size
Quality of Life
Acids
Population

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Endoscopic therapy for GERD : Is the evidence for efficacy any stronger? / Pasricha, Pankaj Jay; Pham, Binh V.

In: Current Treatment Options in Gastroenterology, Vol. 9, No. 1, 02.2006, p. 59-68.

Research output: Contribution to journalArticle

@article{798bc2d6fcf14ab79f33c5cbc88dad11,
title = "Endoscopic therapy for GERD: Is the evidence for efficacy any stronger?",
abstract = "Gastroesophageal reflux disease (GERD) is a common chronic medical disorder that has a significant impact on quality of life and afflicts millions of people worldwide. Therapy with either daily medications or surgical fundoplication, though highly effective for the majority of patients, is not without long-term shortcomings. The development of endoscopic antireflux therapies has been fueled by the hope of providing safe, effective, long-term symptomatic relief. Although several studies have been published, they are limited by small sample size, tack of adequate controls, and a highly selective patient population. However, it is clear that many, if not most, patients will continue to be on acid-suppressive therapy despite these procedures. Also, reports of postmarketing adverse effects emphasize the need for further scrutiny of the safety of these devices. This review will summarize the available evidence and provide tentative conclusions about the current and evolving role of endoscopic antireflux therapy.",
author = "Pasricha, {Pankaj Jay} and Pham, {Binh V.}",
year = "2006",
month = "2",
doi = "10.1007/s11938-006-0024-5",
language = "English (US)",
volume = "9",
pages = "59--68",
journal = "Current Treatment Options in Gastroenterology",
issn = "1092-8472",
publisher = "Current Science, Inc.",
number = "1",

}

TY - JOUR

T1 - Endoscopic therapy for GERD

T2 - Is the evidence for efficacy any stronger?

AU - Pasricha, Pankaj Jay

AU - Pham, Binh V.

PY - 2006/2

Y1 - 2006/2

N2 - Gastroesophageal reflux disease (GERD) is a common chronic medical disorder that has a significant impact on quality of life and afflicts millions of people worldwide. Therapy with either daily medications or surgical fundoplication, though highly effective for the majority of patients, is not without long-term shortcomings. The development of endoscopic antireflux therapies has been fueled by the hope of providing safe, effective, long-term symptomatic relief. Although several studies have been published, they are limited by small sample size, tack of adequate controls, and a highly selective patient population. However, it is clear that many, if not most, patients will continue to be on acid-suppressive therapy despite these procedures. Also, reports of postmarketing adverse effects emphasize the need for further scrutiny of the safety of these devices. This review will summarize the available evidence and provide tentative conclusions about the current and evolving role of endoscopic antireflux therapy.

AB - Gastroesophageal reflux disease (GERD) is a common chronic medical disorder that has a significant impact on quality of life and afflicts millions of people worldwide. Therapy with either daily medications or surgical fundoplication, though highly effective for the majority of patients, is not without long-term shortcomings. The development of endoscopic antireflux therapies has been fueled by the hope of providing safe, effective, long-term symptomatic relief. Although several studies have been published, they are limited by small sample size, tack of adequate controls, and a highly selective patient population. However, it is clear that many, if not most, patients will continue to be on acid-suppressive therapy despite these procedures. Also, reports of postmarketing adverse effects emphasize the need for further scrutiny of the safety of these devices. This review will summarize the available evidence and provide tentative conclusions about the current and evolving role of endoscopic antireflux therapy.

UR - http://www.scopus.com/inward/record.url?scp=33645471868&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33645471868&partnerID=8YFLogxK

U2 - 10.1007/s11938-006-0024-5

DO - 10.1007/s11938-006-0024-5

M3 - Article

C2 - 16423314

AN - SCOPUS:33645471868

VL - 9

SP - 59

EP - 68

JO - Current Treatment Options in Gastroenterology

JF - Current Treatment Options in Gastroenterology

SN - 1092-8472

IS - 1

ER -