Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract

Stephen A. Boppart, Xingde Li, Costas Pitris, Debra L. Stamper, Mark E. Brezinski, James G. Fujimoto

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Technologies capable of imaging subsurface tissue structures offer improved visualization for surgical diagnostics and guidance. Endoscopic ultrasound catheters have been used for imaging the upper and lower gastrointestinal tract with 50-100 μm resolution. However, these resolutions are insufficient to resolve epithelial layers or early epithelial changes which occur in neoplasias and Barrett's esophagus. Optical coherence tomography (OCT) is a fiber-optic based imaging technology capable of acquiring in vivo image data of biological tissue at real-time rates and at resolutions 10 times higher than clinical endoscopic ultrasound. Using a compact amplified super-luminescent diode light source, a portable OCT system has been constructed for use with minimally invasive endoscopic and surgical instruments including catheters, laparoscopes, microscopes, and hand-held surgical probes. The in vivo rabbit gastrointestinal tract is used as a model system. Beam delivery is accomplished with a radial-imaging OCT catheter that can be inserted into the working channel of an endoscope. This in vivo demonstration suggests that resolutions and acquisition rates are sufficient for imaging the human gastrointestinal tract. OCT shows promise for high-resolution image-guidance during diagnostic and surgical procedures.

Original languageEnglish (US)
Title of host publicationProceedings of SPIE - The International Society for Optical Engineering
PublisherSociety of Photo-Optical Instrumentation Engineers
Pages158-164
Number of pages7
Volume3595
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 Biomedical Diagnostic, Guidance, and Surgical-Assist Systems - San Jose, CA, USA
Duration: Jan 26 1999Jan 27 1999

Other

OtherProceedings of the 1999 Biomedical Diagnostic, Guidance, and Surgical-Assist Systems
CitySan Jose, CA, USA
Period1/26/991/27/99

Fingerprint

Optical tomography
tomography
Catheters
Imaging techniques
surgical instruments
esophagus
endoscopes
Ultrasonics
Laparoscopy
Tissue
rabbits
Endoscopy
fiber optics
delivery
acquisition
Image resolution
light sources
diodes
microscopes
Fiber optics

ASJC Scopus subject areas

  • Electrical and Electronic Engineering
  • Condensed Matter Physics

Cite this

Boppart, S. A., Li, X., Pitris, C., Stamper, D. L., Brezinski, M. E., & Fujimoto, J. G. (1999). Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 3595, pp. 158-164). Society of Photo-Optical Instrumentation Engineers.

Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract. / Boppart, Stephen A.; Li, Xingde; Pitris, Costas; Stamper, Debra L.; Brezinski, Mark E.; Fujimoto, James G.

Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3595 Society of Photo-Optical Instrumentation Engineers, 1999. p. 158-164.

Research output: Chapter in Book/Report/Conference proceedingChapter

Boppart, SA, Li, X, Pitris, C, Stamper, DL, Brezinski, ME & Fujimoto, JG 1999, Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 3595, Society of Photo-Optical Instrumentation Engineers, pp. 158-164, Proceedings of the 1999 Biomedical Diagnostic, Guidance, and Surgical-Assist Systems, San Jose, CA, USA, 1/26/99.
Boppart SA, Li X, Pitris C, Stamper DL, Brezinski ME, Fujimoto JG. Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract. In Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3595. Society of Photo-Optical Instrumentation Engineers. 1999. p. 158-164
Boppart, Stephen A. ; Li, Xingde ; Pitris, Costas ; Stamper, Debra L. ; Brezinski, Mark E. ; Fujimoto, James G. / Endoscopic optical coherence tomography imaging for surgical diagnostics and guidance in the gastrointestinal tract. Proceedings of SPIE - The International Society for Optical Engineering. Vol. 3595 Society of Photo-Optical Instrumentation Engineers, 1999. pp. 158-164
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