Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus: Screening, Diagnosis, and Therapy

Massimiliano di Pietro, Marcia Canto, Rebecca C. Fitzgerald

Research output: Contribution to journalArticle

Abstract

Because the esophagus is easily accessible with endoscopy, early diagnosis and curative treatment of esophageal cancer is possible. However, diagnosis is often delayed because symptoms are not specific during early stages of tumor development. The onset of dysphagia is associated with advanced disease, which has a survival at 5 years lower than 15%. Population screening by endoscopy is not cost-effective, but a number of alternative imaging and cell analysis technologies are under investigation. The ideal screening test should be inexpensive, well tolerated, and applicable to primary care. Over the past 10 years, significant progress has been made in endoscopic diagnosis and treatment of dysplasia (squamous and Barrett's), and early esophageal cancer using resection and ablation technologies supported by evidence from randomized controlled trials. We review the state-of-the-art technologies for early diagnosis and minimally invasive treatment, which together could reduce the burden of disease.

Original languageEnglish (US)
Pages (from-to)421-436
Number of pages16
JournalGastroenterology
Volume154
Issue number2
DOIs
StatePublished - Jan 1 2018

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Esophagus
Squamous Cell Carcinoma
Adenocarcinoma
Esophageal Neoplasms
Technology
Endoscopy
Early Diagnosis
Deglutition Disorders
Primary Health Care
Therapeutics
Randomized Controlled Trials
Costs and Cost Analysis
Population
Neoplasms

Keywords

  • Barrett's Esophagus
  • Endoscopy
  • Esophageal Cancer
  • Screening

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Endoscopic Management of Early Adenocarcinoma and Squamous Cell Carcinoma of the Esophagus : Screening, Diagnosis, and Therapy. / di Pietro, Massimiliano; Canto, Marcia; Fitzgerald, Rebecca C.

In: Gastroenterology, Vol. 154, No. 2, 01.01.2018, p. 421-436.

Research output: Contribution to journalArticle

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