Abstract
Background Upper GI endoscopy has an important diagnostic and therapeutic role in the management of nonvariceal upper GI bleeding (NVUGB). Objective To characterize nationwide patterns of utilization of upper GI endoscopy in pregnant women with NVUGB and to assess health outcomes. Design Retrospective cohort study. Setting Participating hospitals from the Nationwide Inpatient Sample, 1998-2007. Patients Pregnant and age-matched nonpregnant women admitted for NVUGB. Intervention The study population was classified as pregnant women with NVUGB (n = 1210) and nonpregnant women with NVUGB (n = 6050). Main Outcome Measurements Rate of upper GI endoscopy, maternal mortality, fetal death/complications, and premature delivery. Results Pregnant women were less likely than nonpregnant women to undergo upper GI endoscopy (26% vs 69%; P <.0001) even after adjustment for comorbidities, transfusion requirement, and the presence of hypovolemic shock (adjusted odds ratio, 0.19; 95% confidence interval, 0.16-0.22). Among those who underwent endoscopy, pregnant women were less likely to undergo the procedure within 24 hours of admission (50% vs 57%; P = .02). Mortality was lower among pregnant women compared with nonpregnant women (0% vs 0.6%; P = .006). In comparing outcomes between those who did and did not undergo endoscopy, there was no difference in fetal loss (0.2% vs 0.6%), fetal distress/complications (2.7% vs 2.6%), or premature delivery (7.3% vs 6.4%). Limitations The study was based on administrative data. Conclusion A conservative nonendoscopic approach is common in the management of pregnant women with NVUGB and is not associated with worse maternal or fetal outcomes. Upper GI endoscopy is, however, safe when judiciously implemented in the actively bleeding patient.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 954-959 |
| Number of pages | 6 |
| Journal | Gastrointestinal Endoscopy |
| Volume | 72 |
| Issue number | 5 |
| DOIs | |
| State | Published - Nov 2010 |
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ASJC Scopus subject areas
- Gastroenterology
- Radiology Nuclear Medicine and imaging
Cite this
Endoscopic management and outcomes of pregnant women hospitalized for nonvariceal upper GI bleeding : A nationwide analysis. / Nguyen, Geoffrey C.; Dinani, Amreen M.; Pivovarov, Kevin.
In: Gastrointestinal Endoscopy, Vol. 72, No. 5, 11.2010, p. 954-959.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Endoscopic management and outcomes of pregnant women hospitalized for nonvariceal upper GI bleeding
T2 - A nationwide analysis
AU - Nguyen, Geoffrey C.
AU - Dinani, Amreen M.
AU - Pivovarov, Kevin
PY - 2010/11
Y1 - 2010/11
N2 - Background Upper GI endoscopy has an important diagnostic and therapeutic role in the management of nonvariceal upper GI bleeding (NVUGB). Objective To characterize nationwide patterns of utilization of upper GI endoscopy in pregnant women with NVUGB and to assess health outcomes. Design Retrospective cohort study. Setting Participating hospitals from the Nationwide Inpatient Sample, 1998-2007. Patients Pregnant and age-matched nonpregnant women admitted for NVUGB. Intervention The study population was classified as pregnant women with NVUGB (n = 1210) and nonpregnant women with NVUGB (n = 6050). Main Outcome Measurements Rate of upper GI endoscopy, maternal mortality, fetal death/complications, and premature delivery. Results Pregnant women were less likely than nonpregnant women to undergo upper GI endoscopy (26% vs 69%; P <.0001) even after adjustment for comorbidities, transfusion requirement, and the presence of hypovolemic shock (adjusted odds ratio, 0.19; 95% confidence interval, 0.16-0.22). Among those who underwent endoscopy, pregnant women were less likely to undergo the procedure within 24 hours of admission (50% vs 57%; P = .02). Mortality was lower among pregnant women compared with nonpregnant women (0% vs 0.6%; P = .006). In comparing outcomes between those who did and did not undergo endoscopy, there was no difference in fetal loss (0.2% vs 0.6%), fetal distress/complications (2.7% vs 2.6%), or premature delivery (7.3% vs 6.4%). Limitations The study was based on administrative data. Conclusion A conservative nonendoscopic approach is common in the management of pregnant women with NVUGB and is not associated with worse maternal or fetal outcomes. Upper GI endoscopy is, however, safe when judiciously implemented in the actively bleeding patient.
AB - Background Upper GI endoscopy has an important diagnostic and therapeutic role in the management of nonvariceal upper GI bleeding (NVUGB). Objective To characterize nationwide patterns of utilization of upper GI endoscopy in pregnant women with NVUGB and to assess health outcomes. Design Retrospective cohort study. Setting Participating hospitals from the Nationwide Inpatient Sample, 1998-2007. Patients Pregnant and age-matched nonpregnant women admitted for NVUGB. Intervention The study population was classified as pregnant women with NVUGB (n = 1210) and nonpregnant women with NVUGB (n = 6050). Main Outcome Measurements Rate of upper GI endoscopy, maternal mortality, fetal death/complications, and premature delivery. Results Pregnant women were less likely than nonpregnant women to undergo upper GI endoscopy (26% vs 69%; P <.0001) even after adjustment for comorbidities, transfusion requirement, and the presence of hypovolemic shock (adjusted odds ratio, 0.19; 95% confidence interval, 0.16-0.22). Among those who underwent endoscopy, pregnant women were less likely to undergo the procedure within 24 hours of admission (50% vs 57%; P = .02). Mortality was lower among pregnant women compared with nonpregnant women (0% vs 0.6%; P = .006). In comparing outcomes between those who did and did not undergo endoscopy, there was no difference in fetal loss (0.2% vs 0.6%), fetal distress/complications (2.7% vs 2.6%), or premature delivery (7.3% vs 6.4%). Limitations The study was based on administrative data. Conclusion A conservative nonendoscopic approach is common in the management of pregnant women with NVUGB and is not associated with worse maternal or fetal outcomes. Upper GI endoscopy is, however, safe when judiciously implemented in the actively bleeding patient.
UR - http://www.scopus.com/inward/record.url?scp=78049335249&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78049335249&partnerID=8YFLogxK
U2 - 10.1016/j.gie.2010.07.018
DO - 10.1016/j.gie.2010.07.018
M3 - Article
C2 - 20875639
AN - SCOPUS:78049335249
VL - 72
SP - 954
EP - 959
JO - Gastrointestinal Endoscopy
JF - Gastrointestinal Endoscopy
SN - 0016-5107
IS - 5
ER -