TY - JOUR
T1 - Endonasal endoscopic resection of esthesioneuroblastoma
T2 - The Johns Hopkins Hospital experience and review of the literature
AU - Gallia, Gary L.
AU - Reh, Douglas D.
AU - Salmasi, Vafi
AU - Blitz, Ari M.
AU - Koch, Wayne
AU - Ishii, Masaru
PY - 2011/10
Y1 - 2011/10
N2 - Esthesioneuroblastoma is an uncommon malignant tumor originating in the upper nasal cavity. The surgical treatment for this tumor has traditionally been via an open craniofacial resection. Over the past decade, there has been tremendous development in endoscopic techniques. In this report, we performed a retrospective analysis of patients with esthesioneuroblastomas treated with a purely endonasal endoscopic approach and resection at the Johns Hopkins Hospital between January 2005 and April 2010. A total of eight patients with esthesioneuroblastoma, five men and three women, were identified. Six patients were treated for primary disease, and two were treated for tumor recurrence. The modified Kadish staging was A in one patient (12.5%), B in two patients (25%), C in four patients (50%), and D in one patient (12.5%). All patients had a complete resection with negative intraoperative margins. One patient had intraoperative hypertension; there were no perioperative complications. With a mean follow-up of over 27 months, all patients are without evidence of disease. In addition, we reviewed the literature and identified several overlapping case series of patients with esthesioneuroblastoma treated via a purely endoscopic technique. Our series adds to the growing experience of expanded endonasal endoscopic surgery in the treatment of skull base tumors including esthesioneuroblastoma. Longer follow-up on a larger number of patients is required to further demonstrate the utility of endoscopic approaches in the management of this malignancy.
AB - Esthesioneuroblastoma is an uncommon malignant tumor originating in the upper nasal cavity. The surgical treatment for this tumor has traditionally been via an open craniofacial resection. Over the past decade, there has been tremendous development in endoscopic techniques. In this report, we performed a retrospective analysis of patients with esthesioneuroblastomas treated with a purely endonasal endoscopic approach and resection at the Johns Hopkins Hospital between January 2005 and April 2010. A total of eight patients with esthesioneuroblastoma, five men and three women, were identified. Six patients were treated for primary disease, and two were treated for tumor recurrence. The modified Kadish staging was A in one patient (12.5%), B in two patients (25%), C in four patients (50%), and D in one patient (12.5%). All patients had a complete resection with negative intraoperative margins. One patient had intraoperative hypertension; there were no perioperative complications. With a mean follow-up of over 27 months, all patients are without evidence of disease. In addition, we reviewed the literature and identified several overlapping case series of patients with esthesioneuroblastoma treated via a purely endoscopic technique. Our series adds to the growing experience of expanded endonasal endoscopic surgery in the treatment of skull base tumors including esthesioneuroblastoma. Longer follow-up on a larger number of patients is required to further demonstrate the utility of endoscopic approaches in the management of this malignancy.
KW - Endoscopic
KW - Endoscopy
KW - Esthesioneuroblastoma
KW - Expanded endonasal approach
KW - Olfactory neuroblastoma
KW - Skull base
UR - http://www.scopus.com/inward/record.url?scp=83155180609&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=83155180609&partnerID=8YFLogxK
U2 - 10.1007/s10143-011-0329-2
DO - 10.1007/s10143-011-0329-2
M3 - Article
C2 - 21655908
AN - SCOPUS:83155180609
SN - 0344-5607
VL - 34
SP - 465
EP - 475
JO - Neurosurgical Review
JF - Neurosurgical Review
IS - 4
ER -