TY - GEN
T1 - Endomicroscopy and biocompatible fluorescent nanocomplexes for clinical translation of high-resolution optical molecular imaging
AU - Xi, Jiefeng
AU - Wu, Yicong
AU - Tae, Hee Kim
AU - Chen, Yongping
AU - Zheng, Desheng
AU - Huo, Li
AU - Cobb, Michael J.
AU - Pun, Suzie
AU - Joo, Ha Hwang
AU - Li, Xingde
PY - 2009/7/24
Y1 - 2009/7/24
N2 - This paper reports on our recent development of two-types of all-fiber-optic scanning endomicroscopy technologies for high-resolution optical imaging of internal organs. The first one is an OCT balloon catheter technology that permits systematic imaging of fine architectural morphologies of internal luminal organs over a large area. The second is a two-photon fluorescence endomicroscopy technology that enables assessment of tissue biochemical/ metabolic information with a superb spatial resolution. Both endomicroscopes have a small diameter (1.2-2.4 mm) and can be readily integrated with a standard clinical gastroscope, providing complementary information about tissue structure and function and helping improve diagnostic yield. We will discuss the basic design principles, major engineering challenges, solutions, and some preliminary results. In addition, we will also present our approach in developing near infrared (NIR) fluorescent nanocomplexes (ICG-micelles), which can be functionalized for active molecular targeting to improve molecular specificity and imaging contrast. These nanocomplexes, made of FDA approved building blocks, are biocompatible and very promising for clinical translation. Ultimately the NIR nanocomplexes can be used in conjunction with endomicroscopy technologies for performing high-resolution optical molecular imaging in vivo and in real time.
AB - This paper reports on our recent development of two-types of all-fiber-optic scanning endomicroscopy technologies for high-resolution optical imaging of internal organs. The first one is an OCT balloon catheter technology that permits systematic imaging of fine architectural morphologies of internal luminal organs over a large area. The second is a two-photon fluorescence endomicroscopy technology that enables assessment of tissue biochemical/ metabolic information with a superb spatial resolution. Both endomicroscopes have a small diameter (1.2-2.4 mm) and can be readily integrated with a standard clinical gastroscope, providing complementary information about tissue structure and function and helping improve diagnostic yield. We will discuss the basic design principles, major engineering challenges, solutions, and some preliminary results. In addition, we will also present our approach in developing near infrared (NIR) fluorescent nanocomplexes (ICG-micelles), which can be functionalized for active molecular targeting to improve molecular specificity and imaging contrast. These nanocomplexes, made of FDA approved building blocks, are biocompatible and very promising for clinical translation. Ultimately the NIR nanocomplexes can be used in conjunction with endomicroscopy technologies for performing high-resolution optical molecular imaging in vivo and in real time.
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U2 - 10.1109/LISSA.2009.4906706
DO - 10.1109/LISSA.2009.4906706
M3 - Conference contribution
AN - SCOPUS:67650727682
SN - 9781424442935
T3 - 2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
SP - 48
EP - 51
BT - 2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
T2 - 2009 IEEE/NIH Life Science Systems and Applications Workshop, LiSSA 2009
Y2 - 9 April 2009 through 10 April 2009
ER -