Endometriosis-associated ovarian carcinoma: Differential expression of vascular endothelial growth factor and estrogen/progesterone receptors

Marcela G. Del Carmen, Anne E.Smith Sehdev, Amanda Nickles Fader, Marianna L. Zahurak, Michael Richardson, John P. Fruehauf, F. J. Montz, Robert Bristow

Research output: Contribution to journalArticle

Abstract

BACKGROUND. Multiple epidemiologic and histologic studies have suggested that ovarian endometriosis can give rise to malignant ovarian tumors, primarily those of epithelial origin. The progression of endometriosis to endometriosis-associated ovarian carcinoma (EAOC) has not been investigated thoroughly and is poorly understood at best. Using immunohistochemical methods, we compared the differential expression patterns of various cytokines and growth factors in atypical endometriosis (AE) and EAOC. METHODS. Using the Johns Hopkins Pathology Data Bank, tissue blocks from patients diagnosed with EAOC or AE were identified. Tissue blocks were stained for 4 markers: vascular endothelial growth factor (VEGF), Ki-67, estrogen receptor (ER), and progesterone receptor (PR). RESULTS. Seventeen cases of EAOC and 8 cases of AE were identified. Staining for VEGF was documented in 16 of 17 (94%) EAOC tissue blocks and in only 1 of 8 (12.5%) AE tissue blocks (P < 0.0001). Only 4 of the 17 (23%) EAOC tissue blocks exhibited positive staining for ER, compared with 8 of 8 (100%) AE tissue blocks (P = 0.0005). Positive staining for PR was noted in only 6 of 17 (35%) EAOC samples but was present in 8 of 8 (100%) AE samples (P = 0.003). Seventy percent of EAOC samples exhibited positive staining for Ki-67, compared with 37.5% of AE samples (P = 0.19). CONCLUSIONS. EAOC appears to be associated with overexpression of VEGF and reduced expression of both ER and PR. Variations in VEGF expression may be associated with the malignant transformation of endometriosis and may present both diagnostic and therapeutic options for the treatment of ovarian malignancies.

Original languageEnglish (US)
Pages (from-to)1658-1663
Number of pages6
JournalCancer
Volume98
Issue number8
DOIs
StatePublished - Oct 15 2003
Externally publishedYes

Keywords

  • Endometriosis
  • Estrogen receptor
  • Ovarian carcinoma
  • Progesterone receptor
  • Vascular endothelial growth factor

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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  • Cite this

    Del Carmen, M. G., Sehdev, A. E. S., Fader, A. N., Zahurak, M. L., Richardson, M., Fruehauf, J. P., Montz, F. J., & Bristow, R. (2003). Endometriosis-associated ovarian carcinoma: Differential expression of vascular endothelial growth factor and estrogen/progesterone receptors. Cancer, 98(8), 1658-1663. https://doi.org/10.1002/cncr.11714