Endometrial thickness after misoprostol use for early pregnancy failure

M. D. Creinin, B. Harwood, R. S. Guido, M. C. Fox, J. Zhang

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


Objectives: To assess if there was any potential relationship between endometrial thickness and final treatment outcome in women successfully treated with misoprostol for a first trimester anembryonic gestation, embryonic demise or fetal demise. Methods: Eighty women were treated with up to two doses of misoprostol 800 μg vaginally for early pregnancy failure. Subjects were scheduled to return 2 (range 1-4), 7 (range 5-9) and 14 (range 12-17) days after treatment. Transvaginal ultrasonography was performed at each follow-up visit. Results: The median endometrial thickness at each of the follow-up visits for women who had expelled the gestational sac was 14 mm, 10 mm, and 7 mm, respectively. The endometrial thickness at the first follow-up visit exceeded 15 mm in 20 subjects (36%) and 30 mm in four subjects (7%). Only three women had a suction aspiration for bleeding after documented expulsion. The endometrial thickness for these women was 11, 13, and 14 mm at the first follow-up visit. Conclusions: There is no obvious relationship between increasing endometrial thickness and the need for surgical intervention in women treated with misoprostol for early pregnancy failure.

Original languageEnglish (US)
Pages (from-to)22-26
Number of pages5
JournalInternational Journal of Gynecology and Obstetrics
Issue number1
StatePublished - Jul 2004
Externally publishedYes


  • Early pregnancy failure
  • Miscarriage
  • Misoprostol
  • Transvaginal ultrasound
  • endometrial thickness

ASJC Scopus subject areas

  • Obstetrics and Gynecology


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