Endometrial receptivities after leuprolide suppression and gonadotropin stimulation: Histology, steroid receptor concentrations, and implantation rates

J. P. Toner, D. K. Hassiakos, S. J. Muasher, J. G. Hsiu, H. W. Jones

Research output: Contribution to journalArticle

Abstract

The effect of markedly supraphysiologic levels of E2 and P4 on the endometrium was assessed by examining endometrial histology, E2 and P4 receptor concentrations, and embryo implantation rates in IVF cycles with and without leuprolide use. Results suggest that 1) the high ovarian response common in leuprolide pretreated cycles can advance endometrial histology, but only up to a certain limit, 2) P4 > 25ng/ml or E2 > 200pg/ml on the day of transfer was associated with non-lagging endometria, 3) implantation rate in high response cycles is not impaired and may be increased, 4) earlier P4 supplementation in low response cycles may be beneficial, 5) extraordinarily high response (E2 > 5000pg/ml) may be detrimental to implantation, and 6) the optimal histology for implantation appears to be at least day 16.

Original languageEnglish (US)
Pages (from-to)220-229
Number of pages10
JournalAnnals of the New York Academy of Sciences
Volume622
StatePublished - 1991
Externally publishedYes

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Leuprolide
Histology
Steroid Receptors
Gonadotropins
Endometrium
Stimulation
Steroids
Implantation
Suppression

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Endometrial receptivities after leuprolide suppression and gonadotropin stimulation : Histology, steroid receptor concentrations, and implantation rates. / Toner, J. P.; Hassiakos, D. K.; Muasher, S. J.; Hsiu, J. G.; Jones, H. W.

In: Annals of the New York Academy of Sciences, Vol. 622, 1991, p. 220-229.

Research output: Contribution to journalArticle

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