Endometrial pathology and estrogens

Zev Rosenwaks, Anne C. Wentz, Georgeanna Seegar Jones, Maria D. Urban, Peter A. Lee, Claude J. Migeon, Tim H. Parmley, J. Donald Woodruff

Research output: Contribution to journalArticle

Abstract

Endometrial biopsies were obtained from 46 hypogonadal patients (44 with gonadal dysgenesis; 2 panhypopituitary) who were receiving estrogen-progestogen therapy. Endometrial abnormalities occurred only in patients receiving a total lifetime conjugated estrogen dose of ≥2500 mg and who had received estrogen treatment for a period longer than 4.2 years. The biopsy outcome was significantly related (P<0.01) to the estrogen dose at time of biopsy and to the total lifetime dose (P<0.05). The progestational drugs administered did not protect against development of endometrial abnormalities. None of the abnormal endometrial patterns were associated with abnormal vaginal bleeding.

Original languageEnglish (US)
Pages (from-to)403-410
Number of pages8
JournalObstetrics and Gynecology
Volume53
Issue number4
StatePublished - 1979

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Estrogens
Pathology
Biopsy
Gonadal Dysgenesis
Conjugated (USP) Estrogens
Uterine Hemorrhage
Progestins
Therapeutics
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Rosenwaks, Z., Wentz, A. C., Jones, G. S., Urban, M. D., Lee, P. A., Migeon, C. J., ... Woodruff, J. D. (1979). Endometrial pathology and estrogens. Obstetrics and Gynecology, 53(4), 403-410.

Endometrial pathology and estrogens. / Rosenwaks, Zev; Wentz, Anne C.; Jones, Georgeanna Seegar; Urban, Maria D.; Lee, Peter A.; Migeon, Claude J.; Parmley, Tim H.; Woodruff, J. Donald.

In: Obstetrics and Gynecology, Vol. 53, No. 4, 1979, p. 403-410.

Research output: Contribution to journalArticle

Rosenwaks, Z, Wentz, AC, Jones, GS, Urban, MD, Lee, PA, Migeon, CJ, Parmley, TH & Woodruff, JD 1979, 'Endometrial pathology and estrogens', Obstetrics and Gynecology, vol. 53, no. 4, pp. 403-410.
Rosenwaks Z, Wentz AC, Jones GS, Urban MD, Lee PA, Migeon CJ et al. Endometrial pathology and estrogens. Obstetrics and Gynecology. 1979;53(4):403-410.
Rosenwaks, Zev ; Wentz, Anne C. ; Jones, Georgeanna Seegar ; Urban, Maria D. ; Lee, Peter A. ; Migeon, Claude J. ; Parmley, Tim H. ; Woodruff, J. Donald. / Endometrial pathology and estrogens. In: Obstetrics and Gynecology. 1979 ; Vol. 53, No. 4. pp. 403-410.
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