Endometrial glycodelin-A expression in the luteal phase of stimulated ovarian cycles

Samuel E. Brown, Erik Mandelin, Sergio Oehninger, James P. Toner, Markku Seppala, Howard W. Jones

Research output: Contribution to journalArticlepeer-review

Abstract

Objective:To determine if controlled ovarian hyperstimulation (COH) affects the endometrial expression of glycodelin-A (GdA) : Prospective, controlled study. Sett : Tertiary infertility clinic. Patient(s): Fifteen oocyte donors undergoing COH cycles and 19 natural-cycle control patients. Intervention(s): COH, endometrial biopsies. Main Outcome Measure(s): Immunohistochemical scoring of endometrial GdA expression, morphologic endometrial dating, and serum E2, LH, and P4 concentrations. Result(s): GdA was detected in all subjects throughout the implantation window period. Immunolocalization was demonstrated in the endometrial glands and not in the stroma or on the surface. A significantly increased proportion of GdA-staining endometrial cells were noted in COH cycle patients as compared with natural-cycling control patients throughout the window of embryo implantation. Both cycle types demonstrated increasing GdA expression throughout the late luteal phase. A significant positive correlation was noted between GdA expression and serum E2 levels (r = 0.5, P<.001) in natural cycles and advanced histology in COH cycles (r = 0.63, P=.01). Neither LH nor P4 were correlated with endometrial GdA expression. Conclusion(s): COH cycles have a significantly increased endometrial GdA expression throughout the implantation phase of the luteal cycle when compared with normal menstrual cycles. The increased expression may affect implantation during COH cycles. Copyright (C) 2000 American Society for Reproductive Medicine.

Original languageEnglish (US)
Pages (from-to)130-133
Number of pages4
JournalFertility and sterility
Volume74
Issue number1
DOIs
StatePublished - Jul 1 2000

Keywords

  • Controlled ovarian hyperstimulation
  • Endometrial receptivity
  • Glycodelin
  • Implantation
  • Natural menstrual cycle

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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