Abstract
A retrospective review was done of 473 patients with histologically proven primary carcinoma of the uterine cervix on whom a dilatation and curettage (D & C) was performed during the initial workup. The pathologic features of the D & C specimens were classified as: (1) endometrial stromal invasion of cervical carcinoma; (2) tumor only, cervical carcinoma in D & C, normal endometrium absent; (3) admixture of normal endometrium and cervical carcinoma (contamination); (4) D & C negative for tumor. The patients were staged according to the FIGO classification. Eighty‐two percent (388) of the patients were treated with radiation alone and the rest with a combination including surgical procedures (usually radical hysterectomy with lymphadenectomy). The three‐ and five‐year survival rates were 10% to 20% lower for patients with D & C showing stromal invasion or tumor only than in patients with admixture or negative D & C. These results were coupled with an appreciably higher number of distant metastases in the patients with positive D & C and a lower incidence in patients with negative D & C. The authors suggest that endometrial extension of carcinoma of the uterine cervix may be an important factor in the staging classification of these patients and recommend that D & C always be done in the initial evaluation. Because of the high incidence of distant metastasis, effective adjuvant therapy must be developed to improve the present therapeutic results.
Original language | English (US) |
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Pages (from-to) | 170-180 |
Number of pages | 11 |
Journal | Cancer |
Volume | 48 |
Issue number | 1 |
DOIs | |
State | Published - Jul 1 1981 |
Externally published | Yes |
ASJC Scopus subject areas
- Oncology
- Cancer Research