Endometrial extension of carcinoma of the uterine cervix: A prognostic factor that may modify staging

Carlos A. Perez, H. Marvin Camel, Frederic Askin, Sherry Breaux

Research output: Contribution to journalArticlepeer-review

44 Scopus citations


A retrospective review was done of 473 patients with histologically proven primary carcinoma of the uterine cervix on whom a dilatation and curettage (D & C) was performed during the initial workup. The pathologic features of the D & C specimens were classified as: (1) endometrial stromal invasion of cervical carcinoma; (2) tumor only, cervical carcinoma in D & C, normal endometrium absent; (3) admixture of normal endometrium and cervical carcinoma (contamination); (4) D & C negative for tumor. The patients were staged according to the FIGO classification. Eighty‐two percent (388) of the patients were treated with radiation alone and the rest with a combination including surgical procedures (usually radical hysterectomy with lymphadenectomy). The three‐ and five‐year survival rates were 10% to 20% lower for patients with D & C showing stromal invasion or tumor only than in patients with admixture or negative D & C. These results were coupled with an appreciably higher number of distant metastases in the patients with positive D & C and a lower incidence in patients with negative D & C. The authors suggest that endometrial extension of carcinoma of the uterine cervix may be an important factor in the staging classification of these patients and recommend that D & C always be done in the initial evaluation. Because of the high incidence of distant metastasis, effective adjuvant therapy must be developed to improve the present therapeutic results.

Original languageEnglish (US)
Pages (from-to)170-180
Number of pages11
Issue number1
StatePublished - Jul 1 1981
Externally publishedYes

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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