Abstract
Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap between lifestyle counseling with or without pharmaceutical treatment and the most effective treatment of obesity, bariatric surgery. Because of its minimally invasive nature, bariatric endoscopic therapy has the potential to appeal to the large sector of the obese population that resists surgery, as well as those early in the onset of obesity. To date, five endoscopic devices have been approved by the U.S. Food and Drug Administration for the treatment of obesity, and many more are in development, undergoing clinical trials, or being used around the world. Here, we present the current state of the field, highlight recent developments, and describe the clinical outcomes of these minimally invasive procedures in terms of weight loss, improvement in metabolic profile, and reduction in comorbidities.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 36-52 |
| Number of pages | 17 |
| Journal | Annals of the New York Academy of Sciences |
| Volume | 1411 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2018 |
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Keywords
- aspiration therapy
- endoscopic sleeve gastroplasty
- gastrointestinal bypass sleeve
- intragastric balloon
- primary obesity surgery endoluminal
- transoral gastroplasty
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science
Cite this
Endoluminal weight loss and metabolic therapies : current and future techniques. / Hill, Christine; Khashab, Mouen; Kalloo, Anthony N; Kumbhari, Vivek.
In: Annals of the New York Academy of Sciences, Vol. 1411, No. 1, 01.01.2018, p. 36-52.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Endoluminal weight loss and metabolic therapies
T2 - current and future techniques
AU - Hill, Christine
AU - Khashab, Mouen
AU - Kalloo, Anthony N
AU - Kumbhari, Vivek
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap between lifestyle counseling with or without pharmaceutical treatment and the most effective treatment of obesity, bariatric surgery. Because of its minimally invasive nature, bariatric endoscopic therapy has the potential to appeal to the large sector of the obese population that resists surgery, as well as those early in the onset of obesity. To date, five endoscopic devices have been approved by the U.S. Food and Drug Administration for the treatment of obesity, and many more are in development, undergoing clinical trials, or being used around the world. Here, we present the current state of the field, highlight recent developments, and describe the clinical outcomes of these minimally invasive procedures in terms of weight loss, improvement in metabolic profile, and reduction in comorbidities.
AB - Obesity is a public health epidemic associated with a number of comorbidities, most notably type 2 diabetes and hypertension, as well as elevated all-cause mortality. The treatment for obesity and its associated comorbidities has most recently expanded into the field of bariatric endoscopy. This field bridges a gap between lifestyle counseling with or without pharmaceutical treatment and the most effective treatment of obesity, bariatric surgery. Because of its minimally invasive nature, bariatric endoscopic therapy has the potential to appeal to the large sector of the obese population that resists surgery, as well as those early in the onset of obesity. To date, five endoscopic devices have been approved by the U.S. Food and Drug Administration for the treatment of obesity, and many more are in development, undergoing clinical trials, or being used around the world. Here, we present the current state of the field, highlight recent developments, and describe the clinical outcomes of these minimally invasive procedures in terms of weight loss, improvement in metabolic profile, and reduction in comorbidities.
KW - aspiration therapy
KW - endoscopic sleeve gastroplasty
KW - gastrointestinal bypass sleeve
KW - intragastric balloon
KW - primary obesity surgery endoluminal
KW - transoral gastroplasty
UR - http://www.scopus.com/inward/record.url?scp=85044151578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85044151578&partnerID=8YFLogxK
U2 - 10.1111/nyas.13441
DO - 10.1111/nyas.13441
M3 - Review article
C2 - 28884820
AN - SCOPUS:85044151578
VL - 1411
SP - 36
EP - 52
JO - Annals of the New York Academy of Sciences
JF - Annals of the New York Academy of Sciences
SN - 0077-8923
IS - 1
ER -