Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Obesity and diabetes are growing health problems in the United States that pose a significant public health burden. It is well established that polycystic ovary syndrome (PCOS), an endocrinopathy of reproductive age women characterized by hyperandrogenism, is associated with an increased risk of subsequent type 2 diabetes. Recent literature in men with clinical hypogonadism of various etiologies shows that they are at increased risk of developing insulin resistance and type 2 diabetes. This suggests that sex hormones in men and women may play a role in regulating glucose metabolism, either through their effects on adiposity or through independent mechanisms. This chapter aims (1) to review the associations of endogenous sex hormones (testosterone, estradiol, and sex hormone-binding globulin) with adiposity, insulin resistance, and type 2 diabetes in men and women; (2) to highlight gender differences and similarities in these associations; and (3) to discuss the pathophysiological mechanisms by which sex hormones may influence insulin sensitivity. To provide a conceptual framework for understanding the gender dimorphism of the association between testosterone and diabetes, it reviews the literature examining the association between diabetes and PCOS in women and hypogonadism in men. However, the majority of the studies reviewed are population-based studies of individuals without clinical gonadal disorders who were not receiving hormone therapy to reduce potential confounding in interpreting the associations.

Original languageEnglish (US)
Title of host publicationPrinciples of Gender-Specific Medicine
PublisherElsevier Inc.
Pages679-693
Number of pages15
ISBN (Print)9780123742711
DOIs
StatePublished - 2010

Fingerprint

Gonadal Steroid Hormones
Type 2 Diabetes Mellitus
Insulin Resistance
Hypogonadism
Polycystic Ovary Syndrome
Adiposity
Gonadal Disorders
Testosterone
Hyperandrogenism
Sex Hormone-Binding Globulin
Estradiol
Public Health
Obesity
Hormones
Glucose
Health
Population
Therapeutics

ASJC Scopus subject areas

  • Dentistry(all)
  • Medicine(all)

Cite this

Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women. / Golden, Sherita Hill.

Principles of Gender-Specific Medicine. Elsevier Inc., 2010. p. 679-693.

Research output: Chapter in Book/Report/Conference proceedingChapter

Golden, Sherita Hill. / Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women. Principles of Gender-Specific Medicine. Elsevier Inc., 2010. pp. 679-693
@inbook{c4fa7e13c19c4087aa19e62a415311bd,
title = "Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women",
abstract = "Obesity and diabetes are growing health problems in the United States that pose a significant public health burden. It is well established that polycystic ovary syndrome (PCOS), an endocrinopathy of reproductive age women characterized by hyperandrogenism, is associated with an increased risk of subsequent type 2 diabetes. Recent literature in men with clinical hypogonadism of various etiologies shows that they are at increased risk of developing insulin resistance and type 2 diabetes. This suggests that sex hormones in men and women may play a role in regulating glucose metabolism, either through their effects on adiposity or through independent mechanisms. This chapter aims (1) to review the associations of endogenous sex hormones (testosterone, estradiol, and sex hormone-binding globulin) with adiposity, insulin resistance, and type 2 diabetes in men and women; (2) to highlight gender differences and similarities in these associations; and (3) to discuss the pathophysiological mechanisms by which sex hormones may influence insulin sensitivity. To provide a conceptual framework for understanding the gender dimorphism of the association between testosterone and diabetes, it reviews the literature examining the association between diabetes and PCOS in women and hypogonadism in men. However, the majority of the studies reviewed are population-based studies of individuals without clinical gonadal disorders who were not receiving hormone therapy to reduce potential confounding in interpreting the associations.",
author = "Golden, {Sherita Hill}",
year = "2010",
doi = "10.1016/B978-0-12-374271-1.00056-3",
language = "English (US)",
isbn = "9780123742711",
pages = "679--693",
booktitle = "Principles of Gender-Specific Medicine",
publisher = "Elsevier Inc.",

}

TY - CHAP

T1 - Endogenous Sex Hormones and Risk of Type 2 Diabetes Mellitus in Men and Women

AU - Golden, Sherita Hill

PY - 2010

Y1 - 2010

N2 - Obesity and diabetes are growing health problems in the United States that pose a significant public health burden. It is well established that polycystic ovary syndrome (PCOS), an endocrinopathy of reproductive age women characterized by hyperandrogenism, is associated with an increased risk of subsequent type 2 diabetes. Recent literature in men with clinical hypogonadism of various etiologies shows that they are at increased risk of developing insulin resistance and type 2 diabetes. This suggests that sex hormones in men and women may play a role in regulating glucose metabolism, either through their effects on adiposity or through independent mechanisms. This chapter aims (1) to review the associations of endogenous sex hormones (testosterone, estradiol, and sex hormone-binding globulin) with adiposity, insulin resistance, and type 2 diabetes in men and women; (2) to highlight gender differences and similarities in these associations; and (3) to discuss the pathophysiological mechanisms by which sex hormones may influence insulin sensitivity. To provide a conceptual framework for understanding the gender dimorphism of the association between testosterone and diabetes, it reviews the literature examining the association between diabetes and PCOS in women and hypogonadism in men. However, the majority of the studies reviewed are population-based studies of individuals without clinical gonadal disorders who were not receiving hormone therapy to reduce potential confounding in interpreting the associations.

AB - Obesity and diabetes are growing health problems in the United States that pose a significant public health burden. It is well established that polycystic ovary syndrome (PCOS), an endocrinopathy of reproductive age women characterized by hyperandrogenism, is associated with an increased risk of subsequent type 2 diabetes. Recent literature in men with clinical hypogonadism of various etiologies shows that they are at increased risk of developing insulin resistance and type 2 diabetes. This suggests that sex hormones in men and women may play a role in regulating glucose metabolism, either through their effects on adiposity or through independent mechanisms. This chapter aims (1) to review the associations of endogenous sex hormones (testosterone, estradiol, and sex hormone-binding globulin) with adiposity, insulin resistance, and type 2 diabetes in men and women; (2) to highlight gender differences and similarities in these associations; and (3) to discuss the pathophysiological mechanisms by which sex hormones may influence insulin sensitivity. To provide a conceptual framework for understanding the gender dimorphism of the association between testosterone and diabetes, it reviews the literature examining the association between diabetes and PCOS in women and hypogonadism in men. However, the majority of the studies reviewed are population-based studies of individuals without clinical gonadal disorders who were not receiving hormone therapy to reduce potential confounding in interpreting the associations.

UR - http://www.scopus.com/inward/record.url?scp=84882557726&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84882557726&partnerID=8YFLogxK

U2 - 10.1016/B978-0-12-374271-1.00056-3

DO - 10.1016/B978-0-12-374271-1.00056-3

M3 - Chapter

SN - 9780123742711

SP - 679

EP - 693

BT - Principles of Gender-Specific Medicine

PB - Elsevier Inc.

ER -