Endogenous sex hormones and glucose tolerance status in postmenopausal women

Research output: Contribution to journalArticle

Abstract

Context: In postmenopausal women, endogenous estradiol (E2) and free testosterone (T) have been positively associated with glucose intolerance and type 2 diabetes. Most studies have not examined these associations in a large group of postmenopausal women. Objective: The objective was to examine the association between endogenous sex hormones and glucose tolerance in postmenopausal women. Design, Setting, and Participants: This was a cross-sectional study of 1973 postmenopausal women ages 45-84 yr, not taking hormone replacement therapy, in the Multi-Ethnic Study of Atherosclerosis baseline examination. Main Outcome Measures: Impaired fasting glucose (IFG) and diabetes were defined based on fasting blood sugar and/or treatment for diabetes. In women with normal glucose tolerance, insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). Results: Increasing quartiles of bioavailable T and E2 and decreasing quartiles of SHBG were associated with significantly increased odds of IFG and diabetes (all P for trend

Original languageEnglish (US)
Pages (from-to)1289-1295
Number of pages7
JournalJournal of Clinical Endocrinology and Metabolism
Volume92
Issue number4
DOIs
StatePublished - Apr 2007

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Gonadal Steroid Hormones
Medical problems
Glucose
Fasting
Insulin Resistance
Insulin
Glucose Intolerance
Hormone Replacement Therapy
Type 2 Diabetes Mellitus
Blood Glucose
Testosterone
Estradiol
Atherosclerosis
Homeostasis
Cross-Sectional Studies
Outcome Assessment (Health Care)
Hormones

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology, Diabetes and Metabolism

Cite this

Endogenous sex hormones and glucose tolerance status in postmenopausal women. / Golden, Sherita Hill; Dobs, Adrian S; Vaidya, Dhananjay; Szklo, Moyses; Gapstur, Susan; Kopp, Peter; Liu, Kiang; Ouyang, Pamela.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 92, No. 4, 04.2007, p. 1289-1295.

Research output: Contribution to journalArticle

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