TY - JOUR
T1 - Endogenous sex hormones and glucose tolerance status in postmenopausal women
AU - Golden, Sherita Hill
AU - Dobs, Adrian S.
AU - Vaidya, Dhananjay
AU - Szklo, Moyses
AU - Gapstur, Susan
AU - Kopp, Peter
AU - Liu, Kiang
AU - Ouyang, Pamela
N1 - Funding Information:
This work was supported by RO1 HL074406 and contracts NO1-HC-95159 through NO1-HC-95165 and NO1-HC-95169 from the National Heart, Lung, and Blood Institute. A full list of participating MESA investigators and institutions can be found at http://www.mesa-nhlbi.org . S.H.G. was supported by a grant through the Robert Wood Johnson Foundation Minority Medical Faculty Development Program (Princeton, NJ) and by a Patient-Oriented Mentored Scientist Award through the National Institute of Diabetes, Digestive, and Kidney Diseases (Bethesda, MD) (5 K23 DK071565).
PY - 2007/4
Y1 - 2007/4
N2 - Context: In postmenopausal women, endogenous estradiol (E2) and free testosterone (T) have been positively associated with glucose intolerance and type 2 diabetes. Most studies have not examined these associations in a large group of postmenopausal women. Objective: The objective was to examine the association between endogenous sex hormones and glucose tolerance in postmenopausal women. Design, Setting, and Participants: This was a cross-sectional study of 1973 postmenopausal women ages 45-84 yr, not taking hormone replacement therapy, in the Multi-Ethnic Study of Atherosclerosis baseline examination. Main Outcome Measures: Impaired fasting glucose (IFG) and diabetes were defined based on fasting blood sugar and/or treatment for diabetes. In women with normal glucose tolerance, insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). Results: Increasing quartiles of bioavailable T and E2 and decreasing quartiles of SHBG were associated with significantly increased odds of IFG and diabetes (all P for trend <0.001). Except for the association of bioavailable T with diabetes, the other associations persisted after multivariable adjustment. Although higher dehydroepiandrostenedione (DHEA) was associated with greater odds of IFG (P for trend = 0.02), it was not associated with diabetes. Of 1100 women with normal glucose tolerance, E2 and DHEA were positively associated, and SHBG was inversely associated with HOMA-IR (all P < 0.001) after multivariable adjustment. Bioavailable T was associated with HOMA-IR (P < 0.001), but not fasting glucose. Conclusion: Of postmenopausal women, endogenous bioavailable T, E2, and DHEA were positively associated and SHBG was negatively associated with insulin resistance.
AB - Context: In postmenopausal women, endogenous estradiol (E2) and free testosterone (T) have been positively associated with glucose intolerance and type 2 diabetes. Most studies have not examined these associations in a large group of postmenopausal women. Objective: The objective was to examine the association between endogenous sex hormones and glucose tolerance in postmenopausal women. Design, Setting, and Participants: This was a cross-sectional study of 1973 postmenopausal women ages 45-84 yr, not taking hormone replacement therapy, in the Multi-Ethnic Study of Atherosclerosis baseline examination. Main Outcome Measures: Impaired fasting glucose (IFG) and diabetes were defined based on fasting blood sugar and/or treatment for diabetes. In women with normal glucose tolerance, insulin resistance was estimated using homeostasis model assessment of insulin resistance (HOMA-IR). Results: Increasing quartiles of bioavailable T and E2 and decreasing quartiles of SHBG were associated with significantly increased odds of IFG and diabetes (all P for trend <0.001). Except for the association of bioavailable T with diabetes, the other associations persisted after multivariable adjustment. Although higher dehydroepiandrostenedione (DHEA) was associated with greater odds of IFG (P for trend = 0.02), it was not associated with diabetes. Of 1100 women with normal glucose tolerance, E2 and DHEA were positively associated, and SHBG was inversely associated with HOMA-IR (all P < 0.001) after multivariable adjustment. Bioavailable T was associated with HOMA-IR (P < 0.001), but not fasting glucose. Conclusion: Of postmenopausal women, endogenous bioavailable T, E2, and DHEA were positively associated and SHBG was negatively associated with insulin resistance.
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U2 - 10.1210/jc.2006-1895
DO - 10.1210/jc.2006-1895
M3 - Article
C2 - 17244779
AN - SCOPUS:34147130918
SN - 0021-972X
VL - 92
SP - 1289
EP - 1295
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 4
ER -