TY - JOUR
T1 - Endogenous sex hormone changes in postmenopausal women in the diabetes prevention program
AU - Kim, Catherine
AU - Kong, Shengchun
AU - Laughlin, Gail A.
AU - Golden, Sherita H.
AU - Mather, Kieren J.
AU - Nan, Bin
AU - Edelstein, Sharon L.
AU - Randolph, John F.
AU - Labrie, Fernand
AU - Buschur, Elizabeth
AU - Barrett-Connor, Elizabeth
PY - 2012/8
Y1 - 2012/8
N2 - Context: Whether endogenous sex hormones (ESH) [SHBG, estradiol, testosterone, and dehydroepiandrosterone (DHEA)] are altered by intensive lifestyle modification (ILS) or metformin and whether such changes affect glucose levels among dysglycemic postmenopausalwomenis unclear. Objectives: Our objective was to examine intervention impact on ESH and associations with fasting plasma glucose (FPG) and 2-h glucose changes among postmenopausal glucose-intolerant women. Design: We performed a secondary analysis of a randomized controlled trial. Participants: Participants included postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n = 382) who participated in the Diabetes Prevention Program. Interventions: Interventions included ILS with the goals of weight reduction of at least 7% of initial weight and 150 min/wk of moderate intensity exercise or metformin or placebo administered 850 mg twice a day. Main Outcome Measures: Intervention-related changes in ESH and associations of changes in ESH and glucose levels were evaluated. Results: ILS significantly increased SHBG and decreased DHEA beforeandafter adjustment for changes in waist circumference and fasting insulin. ILS did not alter estradiol or testosterone.Metformindid not change any ESH. ILS-induced increases in SHBG and declines in DHEA were associated with decreases in FPG and 2-h glucose, and declines in estradiol were associated with decreases in FPG, before and after adjustment for age, FSH, race/ethnicity, changes in waist circumference, and 1/fasting insulin. Conclusions: Among postmenopausal glucose-intolerant women not using estrogen, ILS increased SHBG levels and lowered DHEA levels. These changes were associated with lower glucose independent of adiposity and insulin. Metformin effects upon ESH were not significant.
AB - Context: Whether endogenous sex hormones (ESH) [SHBG, estradiol, testosterone, and dehydroepiandrosterone (DHEA)] are altered by intensive lifestyle modification (ILS) or metformin and whether such changes affect glucose levels among dysglycemic postmenopausalwomenis unclear. Objectives: Our objective was to examine intervention impact on ESH and associations with fasting plasma glucose (FPG) and 2-h glucose changes among postmenopausal glucose-intolerant women. Design: We performed a secondary analysis of a randomized controlled trial. Participants: Participants included postmenopausal, overweight, glucose-intolerant women not using exogenous estrogen (n = 382) who participated in the Diabetes Prevention Program. Interventions: Interventions included ILS with the goals of weight reduction of at least 7% of initial weight and 150 min/wk of moderate intensity exercise or metformin or placebo administered 850 mg twice a day. Main Outcome Measures: Intervention-related changes in ESH and associations of changes in ESH and glucose levels were evaluated. Results: ILS significantly increased SHBG and decreased DHEA beforeandafter adjustment for changes in waist circumference and fasting insulin. ILS did not alter estradiol or testosterone.Metformindid not change any ESH. ILS-induced increases in SHBG and declines in DHEA were associated with decreases in FPG and 2-h glucose, and declines in estradiol were associated with decreases in FPG, before and after adjustment for age, FSH, race/ethnicity, changes in waist circumference, and 1/fasting insulin. Conclusions: Among postmenopausal glucose-intolerant women not using estrogen, ILS increased SHBG levels and lowered DHEA levels. These changes were associated with lower glucose independent of adiposity and insulin. Metformin effects upon ESH were not significant.
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U2 - 10.1210/jc.2012-1233
DO - 10.1210/jc.2012-1233
M3 - Article
C2 - 22689695
AN - SCOPUS:84864810751
SN - 0021-972X
VL - 97
SP - 2853
EP - 2861
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 8
ER -